ArticleScientific reports2019
Identification of somatic alterations in lipoma using whole exome sequencing.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- A case of oral lipoma: from stem to stern.International journal of surgery case reports · 2026Article
- Patterns of Public Interest in Lipomas and Lipoma-Removal Procedures: Google Trends Analysis.JMIR dermatology · 2025Article
- Single-Cell Characterization of Lipomas and Identification of their Adipogenic Progenitors: A Transcriptomic Assessment.The Journal of investigative dermatology · 2022Article
- A compendium of mutational cancer driver genes.Nature reviews. Cancer · 2020Review
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Lipomas are benign fatty tumors with a high prevalence rate, mostly found in adults but have a good prognosis. Until now, reason for lipoma occurrence not been identified. We performed whole exome sequencing to define the mutational spectrum in ten lipoma patients along with their matching control samples. We presented genomic insight into the development of lipomas, the most common benign tumor of soft tissue. Our analysis identified 412 somatic variants including missense mutations, splice site variants, frameshift indels, and stop gain/lost. Copy number variation analysis highlighted minor aberrations in patients. Kinase genes and transcriptions factors were among the validated mutated genes critical for cell proliferation and survival. Pathway analysis revealed enrichment of calcium, Wnt and phospholipase D signaling in patients. In conclusion, whole exome sequencing in lipomas identified mutations in genes with a possible role in development and progression of lipomas.
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Registered trials
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