ArticleScientific reports2019
Estimation of nephron number in living humans by combining unenhanced computed tomography with biopsy-based stereology.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Are noninvasive measurements of nephron number achievable in humans?Current opinion in nephrology and hypertension · 2026Review
- A brief review of some artificial intelligence methods in nephrology.Pediatric nephrology (Berlin, Germany) · 2026Review
- Integrating nephron number into risk stratification for IgA nephropathy.Clinical and experimental nephrology · 2026Article
- Kidney Volume as a Predictor and Modifier of Acute Kidney Injury with Renin-Angiotensin System Inhibitors.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Nephron Number and Kidney Outcomes in IgA Nephropathy: A Retrospective Cohort Study.Kidney360 · 2026Article
- Nephron and Podocyte Metrics in Adolescents With a History of Low Birth Weight: A Three-Case Report.Kidney medicine · 2026Article
- Article
- Development and validation of a single-nephron estimated glomerular filtration rate model to predict disease progression in IgA nephropathy.BMC nephrology · 2025Article
- Nephron number variability in Japanese subjects: an autopsy-based study and its implications for chronic kidney disease: clinical scientist award address 2024.Clinical and experimental nephrology · 2025Review
- Upregulation of Piezo2 and increased extracellular matrix protein in diabetic kidney disease mice.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Estimating baseline creatinine levels based on the kidney parenchymal volume.Clinical and experimental nephrology · 2024Article
- Morphometric analysis of chronicity on kidney biopsy: a useful prognostic exercise.Clinical kidney journal · 2024Review
- Synthesis and Expression of a Targeted, Ferritin-Based Tracer for PET Imaging of Kidney Glomeruli.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery.Cell stem cell · 2022Article
- Delivering on the potential of measuring nephron number in the clinic.Nature reviews. Nephrology · 2022Article
- Nephron mass determines the excretion rate of urinary extracellular vesicles.Journal of extracellular vesicles · 2022Article
- Assessment of nephron number and single-nephron glomerular filtration rate in a clinical setting.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Review
- New imaging tools to measure nephron numberJournal of developmental origins of health and disease · 2021Review
- The old becomes new: advances in imaging techniques to assess nephron mass in children.Pediatric nephrology (Berlin, Germany) · 2021Review
- Mapping nephron mass in vivo using positron emission tomography.American journal of physiology. Renal physiology · 2021Article
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14 authors.
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Abstract
Methods for estimating nephron number in a clinical setting may be useful for predicting renal outcomes. This study aimed to establish such a method using unenhanced computed tomography (CT) and biopsy-based stereology. Patients or living kidney donors simultaneously subjected to enhanced and unenhanced CT examinations were randomly assigned to development and validation groups. The enhanced CT-measured arterial phase and the venous phase images of kidneys were regarded as the true values for cortical volume and parenchymal volume, respectively. Linear multiple regression analysis was used to create models for estimating cortical volume using explanatory variables including unenhanced CT-measured parenchymal volume. Nephron number was determined as the product of cortical volume and the glomerular density in biopsies of donors. Five equations for estimating cortical volume were created and verified. In donors, estimated nephron number by unenhanced CT was consistent with that by enhanced CT, with minimal errors in all models (636-655 ± 210-219 vs. 648 ± 224 × 10
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