ArticleNature communications2019
Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 149 citations in OpenAlex.
- Essential mitochondrial activity in Physcomitrium patens relies on complementary cytochrome and alternative oxidase pathways.The Plant journal : for cell and molecular biology · 2026Article
- Extracellular Polymers fromPolymers · 2026Article
- Tryptophanol enhances nitrogen assimilation in marine diatoms.Nature communications · 2026Article
- Article
- Adaptive reprogramming of carbon-nitrogen metabolism inFrontiers in microbiology · 2026Article
- Increased aluminum exposure induces widespread changes in silicon, carbon, and nitrogen metabolism in Entomoneis vertebralis.BMC genomics · 2025Article
- Nitrogen status exerts dynamic control over phosphorus sensing and acquisition via PSR1 in colimited marine diatoms.Science advances · 2025Article
- Patterns and drivers of diatom diversity and abundance in the global ocean.Nature communications · 2025Article
- Diatom Lensless Imaging Using Laser Scattering and Deep Learning.ACS ES&T water · 2025Article
- Diatom heterotrophy on brown algal polysaccharides emerged through horizontal gene transfer, gene duplication, and neofunctionalization.PLoS biology · 2025Article
- DiatOmicBase: a versatile gene-centered platform for mining functional omics data in diatom research.The Plant journal : for cell and molecular biology · 2025Article
- Optimizing Nitrate and Tryptone to Enhance Growth and Triacylglycerol Accumulation inJournal of microbiology and biotechnology · 2024Article
- Molecular forecasting of domoic acid during a pervasive toxic diatom bloom.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Complementary environmental analysis and functional characterization of lower glycolysis-gluconeogenesis in the diatom plastid.The Plant cell · 2024Article
- ATP homeostasis and signaling in plants.Plant communications · 2024Review
- Article
- A photobioreactor for production of algae biomass from gaseous emissions of an animal house.Applied microbiology and biotechnology · 2023Article
- Validating a Promoter Library for Application in Plasmid-Based Diatom Genetic Engineering.ACS synthetic biology · 2023Article
- Genus-Wide Transcriptional Landscapes Reveal Correlated Gene Networks Underlying Microevolutionary Divergence in Diatoms.Molecular biology and evolution · 2023Article
- Genome analysis of Parmales, the sister group of diatoms, reveals the evolutionary specialization of diatoms from phago-mixotrophs to photoautotrophs.Communications biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diatoms outcompete other phytoplankton for nitrate, yet little is known about the mechanisms underpinning this ability. Genomes and genome-enabled studies have shown that diatoms possess unique features of nitrogen metabolism however, the implications for nutrient utilization and growth are poorly understood. Using a combination of transcriptomics, proteomics, metabolomics, fluxomics, and flux balance analysis to examine short-term shifts in nitrogen utilization in the model pennate diatom in Phaeodactylum tricornutum, we obtained a systems-level understanding of assimilation and intracellular distribution of nitrogen. Chloroplasts and mitochondria are energetically integrated at the critical intersection of carbon and nitrogen metabolism in diatoms. Pathways involved in this integration are organelle-localized GS-GOGAT cycles, aspartate and alanine systems for amino moiety exchange, and a split-organelle arginine biosynthesis pathway that clarifies the role of the diatom urea cycle. This unique configuration allows diatoms to efficiently adjust to changing nitrogen status, conferring an ecological advantage over other phytoplankton taxa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.