ArticleNature communications2019
Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Creating true and false memories from forgotten information in Drosophila.Nature neuroscience · 2026Article
- Spacing effect improves generalization in biological and artificial systems.Patterns (New York, N.Y.) · 2026Article
- Aversive memory and extinction learning for noxious stimuli and aversive tastants in bumblebees.The Journal of experimental biology · 2026Article
- Review
- Twists to Classical Conditioning of AdultCold Spring Harbor protocols · 2025Article
- What could evolve in the evolution of memory?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Single-trial learning leads to mid-term memory formation in ants during an appetitive, but not an aversive, task.Proceedings. Biological sciences · 2025Article
- Memory-like states created by the first ethanol experience are encoded into the Drosophila mushroom body learning and memory circuitry in an ethanol-specific manner.PLoS genetics · 2025Article
- Dancing Glycoproteins: Memory Pattern Formation by Protein Folding through Hydrogen Bonding.Current medicinal chemistry · 2025Article
- Neuronal circuit mechanisms of competitive interaction between action-based and coincidence learning.Science advances · 2024Article
- Oviposition experience affects oviposition preference iniScience · 2024Article
- Review
- Diverse memory paradigms inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Forgotten memory storage and retrieval in Drosophila.Nature communications · 2023Article
- Learning and memory using Drosophila melanogaster: a focus on advances made in the fifth decade of research.Genetics · 2023Article
- Aversive Bimodal Associations Differently Impact Visual and Olfactory Memory Performance iniScience · 2022Article
- Article
- Anesthesia Resistant Memories in Drosophila, a Working Perspective.International journal of molecular sciences · 2022Review
- Exclusion and Co-expression of Aversive Olfactory Long-Term Memories in Drosophila.Neuroscience bulletin · 2022Article
- Understanding the physical basis of memory: Molecular mechanisms of the engram.The Journal of biological chemistry · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is believed that long-term memory (LTM) cannot be formed immediately because it must go through a protein synthesis-dependent consolidation process. However, the current study uses Drosophila aversive olfactory conditioning to show that such processes are dispensable for context-dependent LTM (cLTM). Single-trial conditioning yields cLTM that is formed immediately in a protein-synthesis independent manner and is sustained over 14 days without decay. Unlike retrieval of traditional LTM, which requires only the conditioned odour and is mediated by mushroom-body neurons, cLTM recall requires both the conditioned odour and reinstatement of the training-environmental context. It is mediated through lateral-horn neurons that connect to multiple sensory brain regions. The cLTM cannot be retrieved if synaptic transmission from any one of these centres is blocked, with effects similar to those of altered encoding context during retrieval. The present study provides strong evidence that long-term memory can be formed easily without the need for consolidation.
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