ArticleTranslational psychiatry2019
Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality.Aging cell · 2026Article
- Physiological health Age (PhysAge): a novel multi-system molecular timepiece predicts health and mortality in older adults.GeroScience · 2026Article
- Blood DNA methylation-predicted plasma protein levels and colorectal cancer survival.Clinical epigenetics · 2026Article
- Building epigenetic risk scores of opioid use disorder: Insights from human postmortem brain data.Translational psychiatry · 2026Article
- Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations.Nature communications · 2025Article
- Altered inter-hemispheric and intra-hemispheric functional connectivity dynamics in male cigarette smokers.BMC psychiatry · 2025Article
- Epigenetic clocks and DNA methylation biomarkers of brain health and disease.Nature reviews. Neurology · 2025Review
- DNA methylation-predicted plasma protein levels and breast cancer risk.Breast cancer research : BCR · 2025Article
- Abnormal resting-state effective connectivity of triple network predicts smoking motivations among males.Frontiers in psychiatry · 2025Article
- Lessons we learned from the Lothian Birth Cohorts of 1921 and 1936.Genomic psychiatry : advancing science from genes to society · 2025Article
- DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain.Clinical epigenetics · 2024Article
- The impact of metabolic syndrome on the cerebral cortex: a Mendelian randomization study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Association between physical frailty and cortical structure in middle-aged and elderly people: a Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
- DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication.Epigenetics · 2023Article
- Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations.Genes · 2023Review
- Epigenetic biomarkers for smoking cessation.Addiction neuroscience · 2023Article
- Genetic Associations Between Smoking- and Glaucoma-Related Traits.Translational vision science & technology · 2023Article
- Hypermethylation at CREBBP Is Associated with Cognitive Impairment in a Mexican American Cohort.Journal of Alzheimer's disease : JAD · 2023Article
- Association of DNA methylation signatures with cognitive performance among smokers and ex-smokers.Tobacco induced diseases · 2023Article
- The impact of early adversity on the cerebral cortex - a Mendelian randomization study.Frontiers in neuroscience · 2023Article
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10 authors.
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Abstract
Recent advances in genome-wide DNA methylation (DNAm) profiling for smoking behaviour have given rise to a new, molecular biomarker of smoking exposure. It is unclear whether a smoking-associated DNAm (epigenetic) score has predictive value for ageing-related health outcomes which is independent of contributions from self-reported (phenotypic) smoking measures. Blood DNA methylation levels were measured in 895 adults aged 70 years in the Lothian Birth Cohort 1936 (LBC1936) study using the Illumina 450K assay. A DNA methylation score based on 230 CpGs was used as a proxy for smoking exposure. Associations between smoking variables and health outcomes at age 70 were modelled using general linear modelling (ANCOVA) and logistic regression. Additional analyses of smoking with brain MRI measures at age 73 (n = 532) were performed. Smoking-DNAm scores were positively associated with self-reported smoking status (P < 0.001, eta-squared ɳ
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