ArticleProceedings of the National Academy of Sciences of the United States of America2019
Sublethal antibiotics collapse gut bacterial populations by enhancing aggregation and expulsion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Intestinal motility shapes spatiotemporal patterns of enterohemorrhagicInfection and immunity · 2026Article
- Optimization of bacterial colonization in the gut of axenic and conventional zebrafish larvae using live food.Microbiology spectrum · 2026Article
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- Imaging the impact of rotifer consumption on bacterial behaviors in the zebrafish gut.PloS one · 2026Article
- Long Term Culture of Germ-Free Zebrafish Using Gamma-Irradiated Feeds.bioRxiv : the preprint server for biology · 2025Article
- Phollow reveals in situ phage transmission dynamics in the zebrafish gut microbiome at single-virion resolution.Nature microbiology · 2025Article
- Article
- Antibiotic-mediated microbial community restructuring is dictated by variability in antibiotic-induced lysis rates and population interactions.Nature communications · 2025Article
- Motility genes are associated with the occurrence ofISME communications · 2025Article
- Linking spatial drug heterogeneity to microbial growth dynamics in theory and experiment.bioRxiv : the preprint server for biology · 2024Article
- Antimicrobial Sub-MIC induces Staphylococcus aureus biofilm formation without affecting the bacterial count.BMC infectious diseases · 2024Article
- Bacterial aggregation triggered by low-level antibiotic-mediated lysis.NPJ biofilms and microbiomes · 2024Article
- Unveiling the synergistic potency of chlorhexidine and azithromycin in combined action.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Phollow: Visualizing Gut Bacteriophage Transmission within Microbial Communities and Living Animals.bioRxiv : the preprint server for biology · 2024Article
- Veterinary Drug Residues in the Food Chain as an Emerging Public Health Threat: Sources, Analytical Methods, Health Impacts, and Preventive Measures.Foods (Basel, Switzerland) · 2024Review
- Role of the gut microbiota in tumorigenesis and treatment.Theranostics · 2024Review
- Quorum-sensing gene regulates hormetic effects induced by sulfonamides in Comamonadaceae.Applied and environmental microbiology · 2023Article
- Bacterial c-di-GMP has a key role in establishing host-microbe symbiosis.Nature microbiology · 2023Article
- A mucin-regulated adhesin determines the spatial organization and inflammatory character of a bacterial symbiont in the vertebrate gut.Cell host & microbe · 2023Article
- Antibiotic resistance in bacterial communities.Current opinion in microbiology · 2023Review
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5 authors.
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Abstract
Antibiotics induce large and highly variable changes in the intestinal microbiome even at sublethal concentrations, through mechanisms that remain elusive. Using gnotobiotic zebrafish, which allow high-resolution examination of microbial dynamics, we found that sublethal doses of the common antibiotic ciprofloxacin cause severe drops in bacterial abundance. Contrary to conventional views of antimicrobial tolerance, disruption was more pronounced for slow-growing, aggregated bacteria than for fast-growing, planktonic species. Live imaging revealed that antibiotic treatment promoted bacterial aggregation and increased susceptibility to intestinal expulsion. Intestinal mechanics therefore amplify the effects of antibiotics on resident bacteria. Microbial dynamics are captured by a biophysical model that connects antibiotic-induced collapses to gelation phase transitions in soft materials, providing a framework for predicting the impact of antibiotics on the intestinal microbiome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.