ArticleProceedings of the National Academy of Sciences of the United States of America2019
Creating a neuroprosthesis for active tactile exploration of textures.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Intracortical Somatosensory Stimulation to Elicit Fingertip Sensations in an Individual With Spinal Cord Injury.Neurology · 2022Trial
- Integration of learned artificial sensation with vision during freely moving navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neural mechanisms underlying intracortical microstimulation for sensory restoration.Nature biomedical engineering · 2026Review
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Training-Free Regulation of Grasping by Intracortical Tactile Feedback Designed via S1-M1 Communication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Reward signals in the motor cortex: from biology to neurotechnology.Nature communications · 2025Review
- Brain-machine interface learning is facilitated by specific patterning of distributed cortical feedback.Science advances · 2023Article
- Neural Plasticity in Sensorimotor Brain-Machine Interfaces.Annual review of biomedical engineering · 2023Review
- Neuroprosthetics: from sensorimotor to cognitive disorders.Communications biology · 2023Review
- Brain-machine-brain interfaces as the foundation for the next generation of neuroprostheses.National science review · 2022Article
- Reducing Behavioral Detection Thresholds per ElectrodeFrontiers in neuroscience · 2022Article
- Sputtered ruthenium oxide coatings for neural stimulation and recording electrodes.Journal of biomedical materials research. Part B, Applied biomaterials · 2021Article
- Injecting Information into the Mammalian Cortex: Progress, Challenges, and Promise.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
- Strategies and prospects of effective neural circuits reconstruction after spinal cord injury.Cell death & disease · 2020Review
- Restoring Somatosensation: Advantages and Current Limitations of Targeting the Brainstem Dorsal Column Nuclei Complex.Frontiers in neuroscience · 2020Article
- Dorsal Column Nuclei Neural Signal Features Permit Robust Machine-Learning of Natural Tactile- and Proprioception-Dominated Stimuli.Frontiers in systems neuroscience · 2020Article
- Generating artificial sensations with spinal cord stimulation in primates and rodents.Brain stimulationArticle
- Object Shape and Surface Topology Recognition Using Tactile Feedback Evoked through Transcutaneous Nerve Stimulation.IEEE transactions on hapticsArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Intracortical microstimulation (ICMS) of the primary somatosensory cortex (S1) can produce percepts that mimic somatic sensation and, thus, has potential as an approach to sensorize prosthetic limbs. However, it is not known whether ICMS could recreate active texture exploration-the ability to infer information about object texture by using one's fingertips to scan a surface. Here, we show that ICMS of S1 can convey information about the spatial frequencies of invisible virtual gratings through a process of active tactile exploration. Two rhesus monkeys scanned pairs of visually identical screen objects with the fingertip of a hand avatar-controlled first via a joystick and later via a brain-machine interface-to find the object with denser virtual gratings. The gratings consisted of evenly spaced ridges that were signaled through individual ICMS pulses generated whenever the avatar's fingertip crossed a ridge. The monkeys learned to interpret these ICMS patterns, evoked by the interplay of their voluntary movements and the virtual textures of each object, to perform a sensory discrimination task. Discrimination accuracy followed Weber's law of just-noticeable differences (JND) across a range of grating densities; a finding that matches normal cutaneous sensation. Moreover, 1 monkey developed an active scanning strategy where avatar velocity was integrated with the ICMS pulses to interpret the texture information. We propose that this approach could equip upper-limb neuroprostheses with direct access to texture features acquired during active exploration of natural objects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.