ArticleProceedings of the National Academy of Sciences of the United States of America2019
Experience-dependent structural plasticity at pre- and postsynaptic sites of layer 2/3 cells in developing visual cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions.CNS neuroscience & therapeutics · 2026Review
- Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex.Neuron · 2026Article
- The noncoding circular RNAiScience · 2025Article
- The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity.Neuroprotection (Chichester, England) · 2025Review
- Article
- Stimulus-dependent synaptic plasticity underlies neuronal circuitry refinement in the mouse primary visual cortex.Cell reports · 2024Article
- Real-time visualization of structural dynamics of synapses in live cells in vivo.Nature methods · 2024Article
- Amyloid Pathology Impairs Experience-Dependent Inhibitory Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Single-cell synaptome mapping: its technical basis and applications in critical period plasticity research.Frontiers in neural circuits · 2024Review
- Neurotrophin NT-4/5 Promotes Structural Changes in Neurons of the Developing Visual Cortex.bioRxiv : the preprint server for biology · 2023Article
- Amyloid pathology impairs experience-dependent inhibitory synaptic plasticity.bioRxiv : the preprint server for biology · 2023Article
- Thalamic regulation of a visual critical period and motor behavior.Cell reports · 2023Article
- Production of brain-derived neurotrophic factor gates plasticity in developing visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Toward reframing brain-social dynamics: current assumptions and future challenges.Frontiers in psychiatry · 2023Review
- Most nonpathological eyes present a small area of hyperreflective Henle's fiber layer on pupil-centered optical coherence tomography.International ophthalmology · 2022Article
- Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function.Nature neuroscience · 2022Article
- Review
- [Effects of ring finger and tryptophan-aspartic acid 2 on dendritic spines and synapse formation in cerebral cortex neurons of mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- FosGFP expression does not capture a sensory learning-related engram in superficial layers of mouse barrel cortex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The developing brain can respond quickly to altered sensory experience by circuit reorganization. During a critical period in early life, neurons in the primary visual cortex rapidly lose responsiveness to an occluded eye and come to respond better to the open eye. While physiological and some of the molecular mechanisms of this process have been characterized, its structural basis, except for the well-known changes in the thalamocortical projection, remains obscure. To elucidate the relationship between synaptic remodeling and functional changes during this experience-dependent process, we used 2-photon microscopy to image synaptic structures of sparsely labeled layer 2/3 neurons in the binocular zone of mouse primary visual cortex. Anatomical changes at presynaptic and postsynaptic sites in mice undergoing monocular visual deprivation (MD) were compared to those in control mice with normal visual experience. We found that postsynaptic spines remodeled quickly in response to MD, with neurons more strongly dominated by the deprived eye losing more spines. These postsynaptic changes parallel changes in visual responses during MD and their recovery after restoration of binocular vision. In control animals with normal visual experience, the formation of presynaptic boutons increased during the critical period and then declined. MD affected bouton formation, but with a delay, blocking it after 3 d. These findings reveal intracortical anatomical changes in cellular layers of the cortex that can account for rapid activity-dependent plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.