Evidence map›Paper›PMID 31591205›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

The capping enzyme facilitates promoter escape and assembly of a follow-on preinitiation complex for reinitiation.

Rina Fujiwara, Nivedita Damodaren, Jeremy E Wilusz, Kenji Murakami

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  8. Context-dependent function of the transcriptional regulator Rap1 in gene silencing and activation inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
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  13. Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Review
  15. Review
  16. Insight into promoter clearance by RNA polymerase II.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rina FujiwaraDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Nivedita DamodarenDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Jeremy E WiluszDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Kenji MurakamiDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; kenjim@pennmedicine.upenn.edu.
University of Pennsylvania · USUniversity of California, Los Angeles · US

Funding

Regulatory roles for the Integrator complex and circular RNAsR35GM119735 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WILUSZ, JEREMY E · 2016 to 2025
$4.1M
Functional and structural studies of the transition from transcription initiation to elongationR01GM123233 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MURAKAMI, KENJI · 2017 to 2025
$3.6M
NIGMS NIH HHS R01 GM123233NIGMS NIH HHS R35 GM119735
6 · The paper itself

Abstract

After synthesis of a short nascent RNA, RNA polymerase II (pol II) dissociates general transcription factors (GTFs; TFIIA, TFIIB, TBP, TFIIE, TFIIF, and TFIIH) and escapes the promoter, but many of the mechanistic details of this process remain unclear. Here we developed an in vitro transcription system from the yeast

Indexed as

Promoter Regions, GeneticTranscription, GeneticRNA, FungalRNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscriptional Elongation FactorsTranscription FactorsRNA, FungalRNA Polymerase IISaccharomyces cerevisiae ProteinsTranscriptional Elongation FactorsTranscription Factorscapping enzymepreinitiation complexpromoter escapeRNA polymerase IItranscription

Identifiers

PMID31591205
PMCPMC6842614
OpenAlexW2980047957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.