Evidence map›Paper›PMID 31591196›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Ribosome collisions alter frameshifting at translational reprogramming motifs in bacterial mRNAs.

Angela M Smith, Michael S Costello, Andrew H Kettring, Robert J Wingo, Sean D Moore

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 66 citations in OpenAlex.

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  13. Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  18. Systematic analysis of nonprogrammed frameshift suppression inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Review
  20. Evolution of coronavirus frameshifting elements: Competing stem networks explain conservation and variability.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Angela M SmithBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816.
Michael S CostelloBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816.
Andrew H KettringBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816.
Robert J WingoBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816.
Sean D MooreBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816 Sean.Moore@ucf.edu.ORCID 0000-0003-1606-7771
University of Central Florida · US

Funding

Mechanical Perturbation of Bacterial Translation FidelityR01GM118896 · NIGMS · UNIVERSITY OF CENTRAL FLORIDA · PI MOORE, SEAN DAVID · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM118896
6 · The paper itself

Abstract

Translational frameshifting involves the repositioning of ribosomes on their messages into decoding frames that differ from those dictated during initiation. Some messenger RNAs (mRNAs) contain motifs that promote deliberate frameshifting to regulate production of the encoded proteins. The mechanisms of frameshifting have been investigated in many systems, and the resulting models generally involve single ribosomes responding to stimulator sequences in their engaged mRNAs. We discovered that the abundance of ribosomes on messages containing the

Indexed as

Escherichia coliFrameshifting, RibosomalFrameshift MutationNucleic Acid ConformationPeptide Elongation FactorsProtein BiosynthesisReading FramesRibosomal ProteinsRibosomesRNA, Messengerfactor EF-PPeptide Elongation FactorsRibosomal ProteinsRNA, MessengerbL9dnaXframeshiftribosometranslation

Identifiers

PMID31591196
PMCPMC6815119
OpenAlexW2979331549

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.