ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Insular Cortex Projections to Nucleus Accumbens Core Mediate Social Approach to Stressed Juvenile Rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 73 citations in OpenAlex.
- Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations.Nature neuroscience · 2026Article
- Maternal Social Support Reshapes the Offspring Brain Transcriptome to Buffer Prenatal Stress in Mice.Research square · 2026Article
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Proximity in mice induced by an auditory-conditioned stimulus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A Selective Cortico-Limbic Network Organizes Behavior During Reward Seeking Under Threat.Journal of neuroscience research · 2026Article
- Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptations.Translational psychiatry · 2026Article
- Article
- Affiliation in mice induced by an auditory-conditioned stimulus.bioRxiv : the preprint server for biology · 2026Article
- Oxytocin modulation of the insular cortex: implications for social cognition and neurodevelopmental disorders.Frontiers in neural circuits · 2026Review
- Central neural circuits and their associated mechanisms of inter-organ crosstalk.Frontiers in cell and developmental biology · 2026Review
- Exposure to early-life stress uncovers shared biological signatures underlying vulnerability in the habenula and insular cortex of male and female adult rats.Neurobiology of stress · 2025Article
- Insular input to the prelimbic cortex underlies social affective behavior in rats.bioRxiv : the preprint server for biology · 2025Article
- Modulation of social valence by insular cortex activity during acute social isolation in mice.Molecular brain · 2025Article
- Article
- Sex- and social context-dependent differences in mice fine head movement during social interactions.BMC biology · 2025Article
- Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection.Science advances · 2025Article
- A population of Insula neurons encodes for social preference only after acute social isolation in mice.Nature communications · 2024Article
- Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice.Nature communications · 2024Article
- Detection, processing and reinforcement of social cues: regulation by the oxytocin system.Nature reviews. Neuroscience · 2023Review
- Serotonin modulates social responses to stressed conspecifics via insular 5-HTNeuropharmacology · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Social interactions are shaped by features of the interactants, including age, emotion, sex, and familiarity. Age-specific responses to social affect are evident when an adult male rat is presented with a pair of unfamiliar male conspecifics, one of which is stressed via two foot shocks and the other naive to treatment. Adult test rats prefer to interact with stressed juvenile (postnatal day 30, PN30) conspecifics but avoid stressed adult (PN50) conspecifics. This pattern depends upon the insular cortex (IC), which is anatomically connected to the nucleus accumbens core (NAc). The goal of this work was to test the necessity of IC projections to NAc during social affective behavior. Here, bilateral pharmacological inhibition of the NAc with tetrodotoxin (1 μm; 0.5 μl/side) abolished the preference for stressed PN30, but did not alter interactions with PN50 conspecifics. Using a combination of retrograding tracing and c-Fos immunohistochemistry, we report that social interactions with stressed PN30 conspecifics elicit greater Fos immunoreactivity in IC → NAc neurons than interactions with naive PN30 conspecifics. Chemogenetic stimulation of IC terminals in the NAc increased social exploration with juvenile, but not adult, conspecifics, whereas chemogenetic inhibition of this tract blocked the preference to investigate stressed PN30 conspecifics, which expands upon our previous finding that optogenetic inhibition of IC projection neurons mediated approach and avoidance. These new findings suggest that outputs of IC to the NAc modulate social approach, which provides new insight to the neural circuitry underlying social decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.