Evidence map›Paper›PMID 31591143›Full record

ArticleMolecular and cellular biology2019

Regional Gene Repression by DNA Double-Strand Breaks in G

Caitlin E Purman, Patrick L Collins, Sofia I Porter, Ankita Saini, Harshath Gupta, Barry P Sleckman, Eugene M Oltz

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Type I IFN signaling in the absence of IRGM1 promotesbioRxiv : the preprint server for biology · 2023
    Article
  7. Article
  8. Article
  9. DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders.International journal of molecular sciences · 2022
    Review
  10. Assessing DNA Damage Responses Using B Lymphocyte Cultures.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  11. RNA: a double-edged sword in genome maintenance.Nature reviews. Genetics · 2020
    Review
  12. Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Caitlin E PurmanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Patrick L CollinsDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sofia I PorterDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Ankita SainiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Harshath GuptaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Barry P SleckmanDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA bas2022@med.cornell.edu eugene.oltz@osumc.edu.
Eugene M OltzDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA bas2022@med.cornell.edu eugene.oltz@osumc.edu.
Washington University in St. Louis · USThe Ohio State University · USCornell University · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
ATM FUNCTION DURING V(D)J RECOMBINATIONR01AI074953 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SLECKMAN, BARRY P · 2009 to 2023
$5.9M
MOLECULAR ONCOLOGY TRAINING GRANTT32CA113275 · NCI · WASHINGTON UNIVERSITY · PI Matthew J Walter · 2006 to 2026
$5.7M
CIS-REGULATORY CIRCUITS FOR ILC FUNCTION AND PLASTICITYR01AI134035 · NIAID · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Eugene M Oltz · 2018 to 2026
$4.8M
Topological Control of Antigen Receptor Loci during Lymphocyte DevelopmentR01AI130231 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI BASSING, CRAIG H, OLTZ, EUGENE M · 2017 to 2021
$3.8M
TOPOLOGICAL MECHANISMS OF DNA BREAK REPAIR IN LYMPHOCYTESR37AI118852 · NIAID · OHIO STATE UNIVERSITY · PI Eugene M Oltz · 2021 to 2026
$2.8M
TOPOLOGICAL MECHANISMS OF DNA BREAK REPAIR IN LYMPHOCYTESR01AI118852 · NIAID · WASHINGTON UNIVERSITY · PI OLTZ, EUGENE M · 2015 to 2019
$1.9M
Cis-Regulatory Circuits for ILC Function and PlasticityR56AI134035 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, OLTZ, EUGENE M · 2017 to 2017
$621k
Determining the local transcriptional response to DNA double-strand breaksF31CA203107 · NCI · WASHINGTON UNIVERSITY · PI PURMAN, CAITLIN · 2016 to 2018
$92k
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS F31 CA203107NCI NIH HHS P30 CA091842NCI NIH HHS T32 CA113275NIAID NIH HHS R01 AI074953NIAID NIH HHS R01 AI118852NIAID NIH HHS R01 AI130231NIAID NIH HHS R01 AI134035NIAID NIH HHS R37 AI118852NIAID NIH HHS R56 AI134035
6 · The paper itself

Abstract

DNA damage responses (DDR) to double-strand breaks (DSBs) alter cellular transcription programs at the genome-wide level. Through processes that are less well understood, DSBs also alter transcriptional responses locally, which may be important for efficient DSB repair. Here, we developed an approach to elucidate the

Indexed as

AnimalsCell CycleCell LineDNADNA-Binding ProteinsDNA Breaks, Double-StrandedDNA DamageDNA End-Joining RepairDNA RepairG1 PhaseHumansMiceRegulatory Elements, TranscriptionalSilencer Elements, TranscriptionalDNADNA-Binding ProteinschromatinDNA damageDNA damage signalingnonhomologous DNA end joiningtranscriptional regulation

Identifiers

PMID31591143
PMCPMC6879199
OpenAlexW2979702148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.