ArticleeNeuro
Auditory Cortex Contributes to Discrimination of Pure Tones.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Cortical representation of pitch perception in mice.Communications biology · 2026Article
- An adaptive and flexible role for primary sensory cortex.Nature neuroscience · 2026Review
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- Dissociating instructive from permissive roles of brain circuits with reversible neural activity manipulations.bioRxiv : the preprint server for biology · 2025Article
- Article
- Article
- Rapid emergence of latent knowledge in the sensory cortex drives learning.bioRxiv : the preprint server for biology · 2024Article
- Auditory cortex ensembles jointly encode sound and locomotion speed to support sound perception during movement.PLoS biology · 2023Article
- Corticostriatal Neurons in the Anterior Auditory Field Regulate Frequency Discrimination Behavior.Neuroscience bulletin · 2023Article
- Coupling of Mouse Olfactory Bulb Projection Neurons to Fluctuating Odor Pulses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- What can we learn from inactivation studies? Lessons from auditory cortex.Trends in neurosciences · 2022Review
- Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat.Scientific reports · 2021Article
- Movement-Related Signals in Sensory Areas: Roles in Natural Behavior.Trends in neurosciences · 2020Review
- Neural Correlates of Learning Pure Tones or Natural Sounds in the Auditory Cortex.Frontiers in neural circuits · 2019Article
- Disruption of Early or Late Epochs of Auditory Cortical Activity Impairs Speech Discrimination in Mice.Frontiers in neuroscience · 2019Article
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Authors and funding
3 authors.
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Abstract
The auditory cortex is topographically organized for sound frequency and contains highly selective frequency-tuned neurons, yet the role of auditory cortex in the perception of sound frequency remains unclear. Lesion studies have shown that auditory cortex is not essential for frequency discrimination of pure tones. However, transient pharmacological inactivation has been reported to impair frequency discrimination. This suggests the possibility that successful tone discrimination after recovery from lesion surgery could arise from long-term reorganization or plasticity of compensatory pathways. Here, we compared the effects of lesions and optogenetic suppression of auditory cortex on frequency discrimination in mice. We found that transient bilateral optogenetic suppression partially but significantly impaired discrimination performance. In contrast, bilateral electrolytic lesions of auditory cortex had no effect on performance of the identical task, even when tested only 4 h after lesion. This suggests that when auditory cortex is destroyed, an alternative pathway is almost immediately adequate for mediating frequency discrimination. Yet this alternative pathway is insufficient for task performance when auditory cortex is intact but has its activity suppressed. These results indicate a fundamental difference between the effects of brain lesions and optogenetic suppression, and suggest the existence of a rapid compensatory process possibly induced by injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.