Evidence map›Paper›PMID 31591136›Full record

ArticleLife science alliance2019

Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis.

Manabu Toyoshima, Xuguang Jiang, Tadayuki Ogawa, Tetsuo Ohnishi, Shogo Yoshihara, Shabeesh Balan, Takeo Yoshikawa, Nobutaka Hirokawa

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. International journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Tubulin/microtubules as novel clozapine targets.Neuropsychopharmacology reports · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Manabu ToyoshimaLaboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Japan.ORCID 0000-0001-7291-8935
Xuguang JiangDepartment of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7997-872X
Tadayuki OgawaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.ORCID 0000-0002-4627-0693
Tetsuo OhnishiLaboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Japan.ORCID 0000-0002-6696-9725
Shogo YoshiharaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.ORCID 0000-0001-8633-7285
Shabeesh BalanLaboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Japan.ORCID 0000-0002-1098-1290
Takeo YoshikawaLaboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Japan takeo.yoshikawa@riken.jp.ORCID 0000-0003-2791-6679
Nobutaka HirokawaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan hirokawa@m.u-tokyo.ac.jp.ORCID 0000-0002-0081-5264
RIKEN Center for Brain Science · JPThe University of Tokyo · JPKing Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enhanced carbonyl stress underlies a subset of schizophrenia, but its causal effects remain elusive. Here, we elucidated the molecular mechanism underlying the effects of carbonyl stress in iPS cells in which the gene encoding zinc metalloenzyme glyoxalase I (

Indexed as

Frameshift MutationCell DifferentiationCells, CulturedHumansInduced Pluripotent Stem CellsIntercellular Signaling Peptides and ProteinsLactoylglutathione LyaseMass SpectrometryModels, MolecularNerve Tissue ProteinsProtein CarbonylationProtein ConformationProtein MultimerizationSchizophreniacollapsin response mediator protein-2GLO1 protein, humanIntercellular Signaling Peptides and ProteinsLactoylglutathione LyaseNerve Tissue Proteins

Identifiers

PMID31591136
PMCPMC6781483
OpenAlexW2979155949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.