Evidence map›Paper›PMID 31591128›Full record

ArticleAntimicrobial agents and chemotherapy2019

Amphotericin B Penetrates into the Central Nervous System Through Focal Disruption of the Blood Brain Barrier in Experimental Hematogenous

Vidmantas Petraitis, Ruta Petraitiene, Jessica M Valdez, Vasilios Pyrgos, Martin J Lizak, Brenda A Klaunberg, Darius Kalasauskas, Algidas Basevicius, John D Bacher, Daniel K Benjamin and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. IntracranialJournal of child neurology · 2025
    Pooled it
  2. Brazilian guidelines for the diagnosis and treatment of candidemia and invasive candidiasis in adults and children.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Guideline
  3. JAAD case reports · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Successful Treatment of RefractoryClinical case reports · 2025
    Article
  9. Review
  10. Marine Meroterpenoids Isolated fromPharmaceuticals (Basel, Switzerland) · 2023
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Vidmantas PetraitisTransplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, NY, USA vip2007@med.cornell.edu.
Ruta PetraitieneTransplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, NY, USA.
Jessica M ValdezPediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA.
Vasilios PyrgosPediatric Oncology Branch, National Cancer Institute, Bethesda, MD, USA.
Martin J LizakIn Vivo NMR Center, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD, USA.
Brenda A KlaunbergMouse Imaging Facility, National Institute of Neurological Disorder and Stroke, National Institute of Health, Bethesda, MD, USA.
Darius KalasauskasTransplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, NY, USA.
Algidas BaseviciusDepartment of Radiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
John D BacherDivision of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, MD, USA.
Daniel K BenjaminDuke Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.
William W HopeAntimicrobial Pharmacodynamics and Therapeutics, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool Health Partners, Liverpool, UK.
Thomas J WalshTransplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, NY, USA.
National Institutes of Health · USCornell University · USDuke Medical Center · USJohannes Gutenberg University Mainz · DELithuanian University of Health Sciences · LTNational Cancer Institute · USNewYork–Presbyterian Hospital · USUniversity of Liverpool · GBUniversity of New Mexico · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematogenous

Identifiers

PMID31591128
PMCPMC6879260
OpenAlexW2980032979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.