Evidence map›Paper›PMID 31591117›Full record

ArticleAntimicrobial agents and chemotherapy2019

Early Bayesian Dose Adjustment of Vancomycin Continuous Infusion in Children: a Randomized Controlled Trial.

Romain Berthaud, Sihem Benaboud, Déborah Hirt, Mathieu Genuini, Mehdi Oualha, Martin Castelle, Coralie Briand, Solène Artru, Lorenzo Norsa, Olivia Boyer and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02694458 (Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02694458 nacompletednot on this map

Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2016 to 2017Enrolled100ConditionsMethicillin-resistant Staphylococcal InfectionsArmsEarly vancomycin monitoring and bayesian dosage adjustment, usual vancomycin dose and monitoring strategy
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Methicillin-resistantThe Lancet regional health. Western Pacific · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Romain BerthaudEA 7323 - Pharmacology and Therapeutic Evaluation in children and pregnant women, Paris Descartes University, Sorbonne Paris Cité University, Paris, France. romain.berthaud@aphp.fr.
Sihem BenaboudEA 7323 - Pharmacology and Therapeutic Evaluation in children and pregnant women, Paris Descartes University, Sorbonne Paris Cité University, Paris, France.
Déborah HirtEA 7323 - Pharmacology and Therapeutic Evaluation in children and pregnant women, Paris Descartes University, Sorbonne Paris Cité University, Paris, France.
Mathieu GenuiniPediatric Intensive Care Unit, Necker-Enfants Malades hospital, Assistance Publique-Hoôpitaux de Paris, Paris, France.
Mehdi OualhaEA 7323 - Pharmacology and Therapeutic Evaluation in children and pregnant women, Paris Descartes University, Sorbonne Paris Cité University, Paris, France.
Martin CastelleDepartment of Pediatric Immunology, Hematology and Rheumatology, Necker-Enfants Malades hospital, Assistance Publique-Hoôpitaux de Paris, Paris, France.
Coralie BriandDepartment of Pediatric Immunology, Hematology and Rheumatology, Necker-Enfants Malades hospital, Assistance Publique-Hoôpitaux de Paris, Paris, France.
Solène ArtruDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Necker-Enfants Malades hospital, Assistance Publique-Hoôpitaux de Paris, Paris, France.
Lorenzo NorsaDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Necker-Enfants Malades hospital, Assistance Publique-Hoôpitaux de Paris, Paris, France.
Olivia BoyerDepartment of Pediatric Nephrology, Necker-Enfants Malades hospital, Assistance Publique-Hoôpitaux de Paris, Paris, France.
Frantz FoissacEA 7323 - Pharmacology and Therapeutic Evaluation in children and pregnant women, Paris Descartes University, Sorbonne Paris Cité University, Paris, France.
Naïm BouazzaEA 7323 - Pharmacology and Therapeutic Evaluation in children and pregnant women, Paris Descartes University, Sorbonne Paris Cité University, Paris, France.
Jean-Marc TréluyerEA 7323 - Pharmacology and Therapeutic Evaluation in children and pregnant women, Paris Descartes University, Sorbonne Paris Cité University, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methicillin-resistant staphylococcal infections are a global burden. Area under the serum concentration-time curve to minimum inhibitory concentration (AUC/MIC) ratio is the pharmacokinetic (PK) parameter that best predicts vancomycin efficacy. Its therapeutic range is narrow, difficult to achieve because of a wide intersubject variability, especially in children, and is not routinely targeted since the AUC is rarely available. We investigated if an early Bayesian dose adjustment would increase the rate of vancomycin target attainment, in the first 24 hours of treatment (H24), in children.We conducted a single-centre randomized controlled trial in 4 pediatric departments of Necker-Enfants Malades hospital (Paris, France). Patients aged 3 months to 17 years for whom intravenous vancomycin was started were eligible and randomized in a 1:1 ratio: routine care were compared with an early vancomycin therapeutic drug monitoring (3h after treatment initiation) followed by an early Bayesian dose adjustment using a previously published population-based PK model that included age, bodyweight and serum creatinine as covariates. The primary outcome was the proportion of patients of each group achieving vancomycin therapeutic range at H24, defined by AUC

Identifiers

PMID31591117
PMCPMC6879247

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.