ArticleJournal of food and drug analysis2019
Simultaneous determination of cardiovascular drugs in dried blood spot by liquid chromatography-tandem mass spectrometry.
Article in Journal of food and drug analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Extraction and determination of sartans: Recent advances and analytical perspectives.Journal of pharmaceutical analysis · 2026Review
- Development of an automated device and mobile application for digoxin detection and quantification from dried blood spots using gold-coated magnetic nanoprobes and the lateral-flow immunoassay.Analytical and bioanalytical chemistry · 2025Article
- Dried Blood Spot Analysis for Simultaneous Quantification of Antiepileptic Drugs Using Liquid Chromatography-Tandem Mass Spectrometry.Rapid communications in mass spectrometry : RCM · 2025Article
- Determination of warfarin in volumetric absorptive microsampling by liquid chromatography-tandem mass spectrometry.Heliyon · 2024Article
- Article
- Validation of a quantitative multiplex LC-MS/MS assay of carvedilol, enalaprilat, and perindoprilat in dried blood spots from heart failure patients and its cross validation with a plasma assay.Journal of mass spectrometry and advances in the clinical lab · 2023Article
- Development and Validation of a Dried Blood Spot Assay Using UHPLC-MS/MS to Identify and Quantify 12 Antihypertensive Drugs and 4 Active Metabolites: Clinical Needs and Analytical Limitations.Therapeutic drug monitoring · 2022Article
- Method Development and Validation for Measuring ODrug design, development and therapy · 2021Article
- Validated DBS method for filgotinib quantitation in rat dried blood spots and its application to a pharmacokinetic study in rats.ADMET & DMPK · 2020Article
- Biological sample preparation by using restricted-access nanoparticles prepared from bovine serum albumin: application to liquid chromatographic determination of β-blockers.Mikrochimica acta · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A dried blood spot (DBS) sampling method was exploited to extract cardiovascular drugs using a small volume of whole blood of human and rodent. Thereafter, an analytical method using liquid chromatography with tandem mass spectrometry (LC-MS/MS) was developed and validated for the determination of 12 cardiovascular drugs. A 6 mm internal diameter disc containing 10 μL of blood was punched from a specifically designed card and analyzed by LC-MS/MS using a gradient elution method with a total run time of 16 min. For sample separation, a universal octadecyl-silica column was used with a flow rate of 0.2 mL/min. The developed method was validated in terms of linearity, accuracy, and precision, which showed satisfactory results. In addition, the matrix effects were closely investigated to confirm the extraction efficiency. Additionally, the stability was tested by storing DBSs at room temperature; the results showed that these drugs were stable for at least 30 days. Accordingly, the proposed LC-MS/MS method is capable to analyze several cardiovascular drugs in a single analysis. It can be applied to therapeutic drug monitoring in patients as well as in the in vivo settings.
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