Evidence map›Paper›PMID 31590685›Full record

ArticleBMC research notes2019

Mycobacterium indicus pranii therapy induces tumor regression in MyD88- and TLR2-dependent manner.

Pawan Kumar, Gobardhan Das, Sangeeta Bhaskar

Open access · goldAbstract read
In one paragraph

Article in BMC research notes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Frontiers in immunology · 2024
    Review
  4. Article
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  6. Potential ofOncoimmunology · 2022
    Article
  7. Cytokine Storm and Immunomodulation in COVID-19.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Article
  8. A randomised trial ofERJ open research · 2021
    Article
  9. Review
  10. Indian dermatology online journal
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Pawan KumarPDC-I, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India.
Gobardhan DasSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Sangeeta BhaskarPDC-I, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110067, India. sangeeta@nii.ac.in.
National Institute of Immunology · INJawaharlal Nehru University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMycobacterium indicus pranii (MIP) is an atypical mycobacterium species with potent antitumor efficacy. Macrophages and dendritic cells (DCs) are antigen-presenting cells, playing key roles in the activation of antitumor immunity. We have previously shown the potent activation of macrophages and DCs by MIP, which is mediated by MyD88-TLR2 signaling axis. In the present study, we further examined the role of MyD88 and TLR2 in MIP-mediated tumor regression.

resultsWild-type and MyD88

Indexed as

AnimalsCell Line, TumorDendritic CellsHumansMacrophagesMelanoma, ExperimentalMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88Nontuberculous MycobacteriaSignal TransductionToll-Like Receptor 2Toll-Like Receptor 4Tumor BurdenMyd88 protein, mouseMyeloid Differentiation Factor 88Tlr2 protein, mouseToll-Like Receptor 2Toll-Like Receptor 4Mouse tumor modelMycobacterium indicus praniiMyD88TLRTumor regression

Identifiers

PMID31590685
PMCPMC6781299
OpenAlexW2977947749

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.