ArticleJournal of clinical medicine2019
Alternations of Circadian Clock Genes Expression and Oscillation in Obstructive Sleep Apnea.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- A meta-analysis on the association between obstructive sleep apnea and periodontitis.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Reference Genes for Circadian Profiling of Core Clock Genes in the Blood of Obstructive Sleep Apnea Patients.Biomolecules · 2026Article
- Research status and progress on the relationship between obstructive sleep apnea and pulmonary nodules.Frontiers in medicine · 2026Review
- Exploring differences in signaling pathways of the circadian clock and neuromodulators in obstructive sleep apnea.Scientific reports · 2025Article
- Assessment of continuous positive airway pressure effect on the circadian clock signaling pathway in obstructive sleep apnea patients.Scientific reports · 2025Article
- Time of day dependent reduction in stroke infarct volume by the Reverb agonist SR9009 in mice.Experimental neurology · 2025Article
- Elucidating the Interplay of Hypoxia-Inducible Factor and Circadian Clock Signaling in Obstructive Sleep Apnea Patients.International journal of molecular sciences · 2025Article
- Bidirectional crosstalk between sleep disorders and gynecological cancers: unraveling molecular synergies and precision therapeutics.Frontiers in medicine · 2025Review
- Circadian rhythms and cancer: implications for timing in therapy.Discover oncology · 2024Review
- Circadian Regulation in Diurnal Mammals: Neural Mechanisms and Implications in Translational Research.Biology · 2024Review
- Circadian clock dysregulation: a potential mechanism of depression in obstructive sleep apnea patients.Translational psychiatry · 2024Article
- Investigating the Link between Circadian Clock Gene Expressions, Chronotype, Insomnia, and Daytime Sleepiness in Patients with Obstructive Sleep Apnea.International journal of molecular sciences · 2024Article
- Article
- Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes.Diabetes & metabolism journal · 2024Review
- Article
- Evaluation of clinical and genetic factors in obstructive sleep apnoea.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023Article
- Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases.Cells · 2023Review
- Scalable mixed model methods for set-based association studies on large-scale categorical data analysis and its application to exome-sequencing data in UK Biobank.American journal of human genetics · 2023Article
- Review
- Expression of circadian clock genes in leukocytes of patients with Meniere's disease.Laryngoscope investigative otolaryngology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Circadian misalignment plays an important role in disease processes and can affect disease severity, treatment outcomes, and even survivorship. In this study, we aim to investigate whether expression and daily oscillation patterns of core circadian clock genes were disturbed in patients with obstructive sleep apnea/hypopnea (OSA) syndrome. We performed real-time quantitative reverse transcriptase-polymerase chain reactions to examine the expression of the nine core circadian clock genes in leukocytes of peripheral blood collected at 12 AM, 6 AM, 12 PM, and 6 PM from 133 patients with OSA and 11 normal controls. Daily expression patterns of the nine circadian clock genes were observed in normal controls, but three of these genes (BMAL1, CLOCK, CRY2) were disrupted in patients with OSA. The expressions of eight circadian clock genes (except PER1) at midnight were significantly downregulated in patients with severe OSA. Binary logistic regression analysis selected
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.