Evidence map›Paper›PMID 31590347›Full record

ReviewViruses2019

SV40 Hijacks Cellular Transport, Membrane Penetration, and Disassembly Machineries to Promote Infection.

Yu-Jie Chen, Xiaofang Liu, Billy Tsai

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  9. Review
  10. Review
  11. Membrane Rafts: Portals for Viral Entry.Frontiers in microbiology · 2021
    Review
  12. Article
  13. Review
  14. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yu-Jie ChenDepartment of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 3043, Ann Arbor, MI 48109, USA. chenyuj@med.umich.edu.
Xiaofang LiuDepartment of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 3043, Ann Arbor, MI 48109, USA. xiaofanl@med.umich.edu.
Billy TsaiDepartment of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 3043, Ann Arbor, MI 48109, USA. btsai@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Transport of polyomavirus across the ER membraneR01AI064296 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSAI, BILLY · 2006 to 2021
$5.5M
Hijacking a unique subcellular structure during viral entry to cause infectionR21AI140449 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSAI, BILLY · 2019 to 2020
$429k
NIAID NIH HHS R01 AI064296NIAID NIH HHS R21 AI140449NIH HHS R21AI140449 to BTNIH HHS RO1AI064296
6 · The paper itself

Abstract

During entry, a virus must be transported through the endomembrane system of the host cell, penetrate a cellular membrane, and undergo capsid disassembly, to reach the cytosol and often the nucleus in order to cause infection. To do so requires the virus to coordinately exploit the action of cellular membrane transport, penetration, and disassembly machineries. How this is accomplished remains enigmatic for many viruses, especially for viruses belonging to the nonenveloped virus family. In this review, we present the current model describing infectious entry of the nonenveloped polyomavirus (PyV) SV40. Insights from SV40 entry are likely to provide strategies to combat PyV-induced diseases, and to illuminate cellular trafficking, membrane transport, and disassembly mechanisms.

Indexed as

Biological TransportCell NucleusCytosolEndocytosisEndoplasmic ReticulumEndosomesGolgi ApparatusHumansMembranesPolyomavirus InfectionsSimian virus 40Tumor Virus InfectionsVirus AssemblyVirus InternalizationVirus Replicationendoplasmic reticulummembrane penetrationnonenveloped virusSV40viral disassembly

Identifiers

PMID31590347
PMCPMC6832212
OpenAlexW2977595851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.