Evidence map›Paper›PMID 31590343›Full record

ReviewJournal of clinical medicine2019

Follow-Up Recommendations after Curative Resection of Well-Differentiated Neuroendocrine Tumours: Review of Current Evidence and Clinical Practice.

Angela Lamarca, Hamish Clouston, Jorge Barriuso, Mairéad G McNamara, Melissa Frizziero, Was Mansoor, Richard A Hubner, Prakash Manoharan, Sarah O'Dwyer, Juan W Valle

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. SEOM-GETNE clinical guidelines for the diagnosis and treatment of gastroenteropancreatic and bronchial neuroendocrine neoplasms (NENs) (2022).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
  9. Article
  10. A multigenomic liquid biopsy biomarker for neuroendocrine tumor disease outperforms CgA and has surgical and clinical utility.Annals of oncology : official journal of the European Society for Medical Oncology · 2021
    Observational
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Angela LamarcaMedical Oncology Department, The Christie NHS Foundation Trust, Manchester M20 4BX, UK. angela.lamarca@christie.nhs.uk.
Hamish CloustonSurgery Department, Colorectal and Peritoneal Oncology Centre, The Christe NHS Foundation Trust, Manchester M20 4BX, UK. Hamish.Clouston@christie.nhs.uk.
Jorge BarriusoMedical Oncology Department, The Christie NHS Foundation Trust, Manchester M20 4BX, UK. Jorge.Barriuso@manchester.ac.uk.
Mairéad G McNamaraMedical Oncology Department, The Christie NHS Foundation Trust, Manchester M20 4BX, UK. mairead.mcnamara@christie.nhs.uk.
Melissa FrizzieroMedical Oncology Department, The Christie NHS Foundation Trust, Manchester M20 4BX, UK. Melissa.Frizziero@christie.nhs.uk.
Was MansoorMedical Oncology Department, The Christie NHS Foundation Trust, Manchester M20 4BX, UK. Was.Mansoor@christie.nhs.uk.
Richard A HubnerMedical Oncology Department, The Christie NHS Foundation Trust, Manchester M20 4BX, UK. Richard.Hubner@christie.nhs.uk.
Prakash ManoharanRadiology and Nuclear Medicine Department, The Christie NHS Foundation Trust, Manchester M20 4BX, UK. Prakash.Manoharan@christie.nhs.uk.
Sarah O'DwyerDivision of Cancer Sciences, University of Manchester, Manchester M13 9PL, UK. Sarah.O'Dwyer@christie.nhs.uk.
Juan W ValleMedical Oncology Department, The Christie NHS Foundation Trust, Manchester M20 4BX, UK. juan.valle@christie.nhs.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of neuroendocrine neoplasms (NENs) is increasing, especially for patients with early stages and grade 1 tumours. Current evidence also shows increased prevalence, probably reflecting earlier stage diagnosis and improvement of treatment options. Definition of adequate postsurgical follow-up for NENs is a current challenge. There are limited guidelines, and heterogeneity in adherence to those available is notable. Unfortunately, the population of patients at greatest risk of recurrence has not been defined clearly. Some studies support that for patients with pancreatic neuroendocrine tumours (PanNETs), factors such as primary tumour (T), stage, grade (Ki-67), tumour size, and lymph node metastases (N) are of relevance. For bronchial neuroendocrine tumours (LungNETs) and small intestinal neuroendocrine tumours (siNETs), similar factors have been identified. This review summarises the evidence supporting the rationale behind follow-up after curative resection in well-differentiated PanNETs, siNETs, and LungNETS. Published evidence informing relapse rate, disease-free survival, and relapse patterns are discussed, together with an overview of current guidelines informing postsurgical investigations and duration of follow-up.

Indexed as

curative surgeryfollow-upguidelinesneuroendocrine neoplasmsneuroendocrine tumoursrecurrencerelapseresectionrisk factor

Identifiers

PMID31590343
PMCPMC6833016

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.