Evidence map›Paper›PMID 31590289›Full record

ArticleMolecules (Basel, Switzerland)2019

Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation.

Victor Kartsev, Athina Geronikaki, Silvia Bua, Alessio Nocentini, Anthi Petrou, Boris Lichitsky, Mykhaylo Frasinyuk, Janis Leitans, Andris Kazaks, Kaspars Tars and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 5 countries.

Victor KartsevInterBioscreen, 119019 Moscow, Russia. vkartsev@ibscreen.chg.ru.
Athina GeronikakiSchool of Health, Department of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. geronikaki@gmail.com.
Silvia BuaDipartimento Neurofarba, Sezione Di Scienze Farmaceutiche e Nutraceutiche, Universita' Degli Studi Di Firenze, Sesto Fiorentino, 50019 Florence, Italy. silvia.bua@unifi.it.
Alessio NocentiniDipartimento Neurofarba, Sezione Di Scienze Farmaceutiche e Nutraceutiche, Universita' Degli Studi Di Firenze, Sesto Fiorentino, 50019 Florence, Italy. alessio.nocentini@unifi.it.
Anthi PetrouSchool of Health, Department of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. anthi.petrou.thessaloniki1@gmail.com.
Boris LichitskyZelinsky Institute of Organic Chemistry, Leninsky prospect, 119991, Moscow, Russia. blich2006@mail.ru.
Mykhaylo FrasinyukInstitute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 02094 Kiev, Ukraine. mykhaylo.frasinyuk@ukr.net.
Janis LeitansLatvian Biomedical Research and Study Center, Ratsupites 1, LV-1067 Riga, Latvia. janis.leitans@biomed.lu.lv.
Andris KazaksLatvian Biomedical Research and Study Center, Ratsupites 1, LV-1067 Riga, Latvia. andris@biomed.lu.lv.
Kaspars TarsLatvian Biomedical Research and Study Center, Ratsupites 1, LV-1067 Riga, Latvia. kaspars@biomed.lu.lv.
Claudiu T SupuranDipartimento Neurofarba, Sezione Di Scienze Farmaceutiche e Nutraceutiche, Universita' Degli Studi Di Firenze, Sesto Fiorentino, 50019 Florence, Italy. claudiu.supuran@unifi.it.
Istituto Nazionale di Fisica Nucleare, Sezione di Firenze · ITLatvian Biomedical Research and Study Centre · LVAristotle University of Thessaloniki · GRN.D. Zelinsky Institute of Organic Chemistry · RUTransgenomic (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbonic anhydrases (CAs, EC 4.2.1.1) catalyze the fundamental reaction of CO

Indexed as

Antigens, NeoplasmCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesCatalytic DomainComputer SimulationCoumarinsHumansModels, MolecularMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntigens, NeoplasmCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic Anhydrasescarbonic anhydrase XIICoumarinscarbonic anhydrasecoumarindockingprodrugselectivitytumor-associated isoform

Identifiers

PMID31590289
PMCPMC6804193
OpenAlexW2978430549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.