Evidence map›Paper›PMID 31590268›Full record

ReviewPathogens (Basel, Switzerland)2019

Direct-Acting Antiviral Agents for HCV-Associated Glomerular Disease and the Current Evidence.

Fabrizio Fabrizi, Roberta Cerutti, Giulia Porata, Piergiorgio Messa, Ezequiel Ridruejo

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Renal Manifestations of Chronic Hepatitis C: A Review.Journal of clinical medicine · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Inflammation and kidney involvement in human viral diseases caused by SARS-CoV-2, HIV, HCV and HBV.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Fabrizio FabriziFoundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy. fabrizio.fabrizi@policlinico.mi.it.
Roberta CeruttiFoundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy. roberta.cerutti@policlinico.mi.it.
Giulia PorataFoundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy. Giulia.porata@policlinico.mi.it.
Piergiorgio MessaFoundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy. Piergiorgio.messa@policlinico.mi.it.
Ezequiel RidruejoHepatology Section, Department of Medicine, Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno ''CEMIC'', Ciudad Autonoma de Buenos Aires C1425ASG, Argentina. eridruejo@gmail.com.
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHospital Universitario Austral · ARUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glomerular disease is an extra-hepatic manifestation of hepatitis C virus infection (HCV) and membranoproliferative glomerulonephritis is the most frequent glomerular disease associated with HCV. It occurs commonly in patients with HCV-related mixed cryoglobulinemia syndrome. Patients with HCV-related glomerular disease have been historically a difficult-to-treat group. The therapeutic armamentarium for HCV-related glomerular disease now includes antiviral regimens, selective or non-specific immunosuppressive drugs, immunomodulators, and symptomatic agents. The treatment of HCV-associated glomerular disease is dependent on the clinical presentation of the patient. The recent introduction of all-oral, interferon (IFN)-free/ribavirin (RBV)-free regimens is dramatically changing the course of HCV in the general population, and some regimens have been approved for HCV even in patients with advanced chronic kidney disease. According to a systematic review of the medical literature, the evidence concerning the efficacy/safety of direct-acting antiviral agents (DAAs) of HCV-induced glomerular disease is limited. The frequency of sustained virological response was 92.5% (62/67). Full or partial clinical remission was demonstrated in many patients (

Indexed as

direct-acting antiviral agentsglomerulonephritishepatitis C virusmixed cryoglobulinemiaproteinuriasustained virological response

Identifiers

PMID31590268
PMCPMC6963560
OpenAlexW2977360772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.