Evidence map›Paper›PMID 31589412›Full record

ArticleBioconjugate chemistry2019

Water-Soluble Nanoconjugate for Enhanced Cellular Delivery of Receptor-Targeted Magnetic Resonance Contrast Agents.

Laura K Moore, Michael A Caldwell, Taryn R Townsend, Keith W MacRenaris, Georgette Moyle-Heyrman, Nikhil Rammohan, Erika K Schonher, Joanna E Burdette, Dean Ho, Thomas J Meade

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura K MooreDepartment of Biomedical Engineering, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States.
Michael A CaldwellDepartments of Chemistry, Molecular Biosciences, Neurobiology, and Radiology , Northwestern University , Evanston , Illinois 60208 , United States.
Taryn R TownsendDepartments of Chemistry, Molecular Biosciences, Neurobiology, and Radiology , Northwestern University , Evanston , Illinois 60208 , United States.
Keith W MacRenarisDepartments of Chemistry, Molecular Biosciences, Neurobiology, and Radiology , Northwestern University , Evanston , Illinois 60208 , United States.
Georgette Moyle-HeyrmanDepartment of Medicinal Chemistry and Pharmacognosy , University of Illinois at Chicago , Chicago , Illinois 60607 , United States.
Nikhil RammohanDepartments of Chemistry, Molecular Biosciences, Neurobiology, and Radiology , Northwestern University , Evanston , Illinois 60208 , United States.
Erika K SchonherDepartments of Chemistry, Molecular Biosciences, Neurobiology, and Radiology , Northwestern University , Evanston , Illinois 60208 , United States.
Joanna E BurdetteDepartment of Medicinal Chemistry and Pharmacognosy , University of Illinois at Chicago , Chicago , Illinois 60607 , United States.ORCID 0000-0002-7271-6847
Dean HoThe N.1 Institute for Health (N.1) , National University of Singapore , Singapore 117556.
Thomas J MeadeDepartment of Biomedical Engineering, Feinberg School of Medicine , Northwestern University , Chicago , Illinois 60611 , United States.ORCID 0000-0001-6202-1155

Funding

Botanical derived progestins and their impact on women's healthR01AT008824 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Joanna E Burdette, Brian Thacher Murphy · 2016 to 2026
$3.3M
Chemistry of Life Processes Predoctoral Training ProgramT32GM105538 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2013 to 2022
$2.7M
q-Modulated Magnetic Resonance Imaging Contrast AgentsR01EB005866 · NIBIB · NORTHWESTERN UNIVERSITY · PI MEADE, THOMAS J · 2005 to 2013
$2.2M
Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine DiseaseR01EB014806 · NIBIB · NORTHWESTERN UNIVERSITY · PI MEADE, THOMAS J · 2012 to 2015
$1.4M
Targeted Delivery of Nanodiamonds for Breast Cancer Imaging and TherapyF30CA174156 · NCI · NORTHWESTERN UNIVERSITY · PI MOORE, LAURA K. · 2013 to 2016
$170k
NCCIH NIH HHS R01 AT008824NCI NIH HHS F30 CA174156NIBIB NIH HHS R01 EB005866NIBIB NIH HHS R01 EB014806NIGMS NIH HHS T32 GM105538
6 · The paper itself

Abstract

ProGlo is an efficient steroid receptor-targeted magnetic resonance (MR) imaging contrast agent (CA). It has been shown to bind to the progesterone receptor (PR) and produce enhanced image contrast in PR-positive cells and tissues

Indexed as

AnimalsBreast NeoplasmsContrast MediaFemaleHumansMagnetic Resonance ImagingMiceNanoconjugatesNanodiamondsReceptors, ProgesteroneSolubilityTissue DistributionTumor Cells, CulturedContrast MediaNanoconjugatesNanodiamondsReceptors, Progesterone

Identifiers

PMID31589412
PMCPMC6868311

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.