Evidence map›Paper›PMID 31589406›Full record

ReviewACS nano2019

Tracking Single Molecules in Biomembranes: Is Seeing Always Believing?

Yanqi Yu, Miao Li, Yan Yu

Abstract readReview
In one paragraph

Review in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Advanced optical microscopy methods forBiophysical reviews · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yanqi YuDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.
Miao LiDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.
Yan YuDepartment of Chemistry , Indiana University , Bloomington , Indiana 47405 , United States.ORCID 0000-0001-6496-5045

Funding

Unravelling Mechanisms of Endosomal Signaling with Designer NanomaterialsR35GM124918 · NIGMS · WASHINGTON UNIVERSITY · PI Yan Yu · 2017 to 2026
$3.8M
NIGMS NIH HHS R35 GM124918
6 · The paper itself

Abstract

The spatial organization of molecules in cell membranes and their dynamic interactions play a central role in regulating cell functions. Single-particle tracking (SPT), a technique in which single molecules are imaged and tracked in real time, has led to breakthrough discoveries regarding these spatiotemporal complexities of cell membranes. There are, however, emerging concerns about factors that might produce misleading interpretations of SPT results. Here, we briefly review the application of SPT to understanding the nanoscale heterogeneities of plasma membranes, with a focus on the unique challenges, pitfalls, and limitations that confront the use of nanoparticles as imaging probes for tracking the dynamics of single molecules in cell membranes.

Indexed as

Cell MembraneImage Processing, Computer-AssistedNanoparticlesNanotechnologySingle Molecule Imaging

Identifiers

PMID31589406
PMCPMC7179047

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.