ArticleJBRA assisted reproduction2020
Immature oocyte incidence: Contributing factors and effects on mature sibling oocytes in intracytoplasmic sperm injection cycles.
Article in JBRA assisted reproduction, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Effect of early rescue ICSI in multiple cycles of couples with successful fertilization in the initial cycle of conventional IVF.Journal of ovarian research · 2025Article
- Oocyte maturation defect in women undergoing IVF: contributing factors and effects on mature sibling oocyte outcomes.Journal of assisted reproduction and genetics · 2025Article
- In Vitro Maturation and Time-Lapse Imaging of Immature Human Oocytes: A Direction Toward Clinical Applications.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Dual triggering for final oocyte maturation. A narrative review.Frontiers in endocrinology · 2025Review
- Stereological study of organelle distribution in human mature oocytes.Scientific reports · 2024Article
- Detecting partial premature ovulation during follicular aspiration compromises the quantity, but not the quality, of the oocytes retrieved in stimulated in vitro fertilization (IVF) cycles.JBRA assisted reproduction · 2024Article
- Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin and Body Mass Index PredictsInternational journal of fertility & sterility · 2023Article
- The effect of large follicle puncture and aspiration on the outcomes of IVF-ET in patients with asynchronized follicles under the long GnRH-a protocol: a retrospective cohort study.BMC pregnancy and childbirth · 2023Article
- Rescue IVM of Denuded GV- and MI-Stage Oocytes of Premenopausal Rats with Oncostatin M, Insulin-like Growth Factor I, and Growth Hormone.Life (Basel, Switzerland) · 2022Article
- Evaluation of Protocols of Controlled Ovarian Stimulation in Obtaining Mature Oocytes (MII): Retrospective Study on Assisted Reproductive Technology Procedures.JBRA assisted reproduction · 2022Article
- GVBD rate is an independent predictor for pregnancy in ICSI patients with surplus immature oocytes.Frontiers in endocrinology · 2022Article
- Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application.Human reproduction open · 2022Review
- The usefulness of metaphase I oocytes in women who undergo controlled ovarian hyperstimulation for intracytoplasmic sperm injection.JBRA assisted reproduction · 2021Article
- Oocyte Competence Biomarkers Associated With Oocyte Maturation: A Review.Frontiers in cell and developmental biology · 2021Review
- Calcium ionophore supplementation for immature oocytes and pentoxifylline supplementation for immotile sperms: A study of embryo quality of difficult cases inJournal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to investigate which factors contribute to the incidence of immature oocytes (germinal vesicle -GV- and metaphase I -MI-) and how they impact the intracytoplasmic sperm injection (ICSI) outcomes of sibling mature oocytes.
methodsData from 3,920 cycles performed from June/2010 to August/2016 in a private university-affiliated IVF center were evaluated for the influence of controlled ovarian stimulation protocol (COS) on immature oocytes incidence and its effects on ICSI outcomes.
resultsMI (p=0.004) and GV (p=0.029) number were negatively correlated with gonadotropin dose. Patients stimulated by rFSH had increased GV/oocyte rate in both GnRH agonists (p<0.001) and antagonist (p=0.042) protocols, in comparison to rFSH associated with rLH protocol. MI and GV/oocyte rates were negatively correlated to fertilization (p<0.001), high-quality embryo on da p<0.001; GV/oocyte p=0.033) and pregnancy (MI/oocyte p=0.002; GV/oocyte p=0.013) rates. Cycles above a 10.5% MI/oocyte cut-off were correlated to higher response to ovarian stimulation, poor embryo development and almost two times lower pregnancy rate. Immature oocyte incidence is affected by COS and impacts on ICSI outcomes.
conclusionOur evidence suggests that oocytes derived from a cohort with high incidence of maturation fail may have detrimental clinical outcomes.
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