Evidence map›Paper›PMID 31588852›Full record

ArticleJournal of biomolecular structure & dynamics2020

Characterization of an engineered water-soluble variant of the full-length human mu opioid receptor.

Jin Xi, Jie Xiao, Jose Manuel Perez-Aguilar, Jinglei Ping, A T Charlie Johnson, Jeffery G Saven, Renyu Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Activation dynamics of a water-soluble human mu-opioid receptor.The Journal of biological chemistry · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jin XiDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.
Jie XiaoDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.
Jose Manuel Perez-AguilarDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Jinglei PingDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA.
A T Charlie JohnsonDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA.
Jeffery G SavenDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Renyu LiuDepartment of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USBenemérita Universidad Autónoma de Puebla · MX

Funding

Water soluble variants of the human mu opioid receptorR01GM111421 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LIU, RENYU · 2014 to 2018
$1.7M
NIGMS NIH HHS R01 GM111421
6 · The paper itself

Abstract

A water-soluble variant of the transmembrane domain of the human mu opioid receptor (wsMOR-TM) was previously characterized. This study explored whether the full-length version of the engineered water-soluble receptor, (wsMOR-FL), could be overexpressed in

Indexed as

Escherichia coliReceptors, Opioid, muHumansProtein Structure, SecondarySolubilityWaterReceptors, Opioid, muWaterGPCRhuman mu opioid receptorthermostabilitywater-soluble variant

Identifiers

PMID31588852
PMCPMC7162730
OpenAlexW2979847686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.