ArticleAmerican journal of physiology. Renal physiology2019
Glucocorticoid receptor activation stimulates the sodium-chloride cotransporter and influences the diurnal rhythm of its phosphorylation.
Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Dietary salt impairs circadian physiological metabolic adaptations in salt-sensitive hypertension.Function (Oxford, England) · 2026Article
- Localisation of corticosteroids in male mouse kidney by mass spectrometry imaging.Journal of molecular endocrinology · 2026Article
- Chronic ACTH Infusion Alters the Diurnal Rhythm of Sodium Excretion, Inducing Nondipping Blood Pressure and Salt-Sensitivity in Male Mice.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Kidney-specific WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates.The Journal of clinical investigation · 2025Article
- A 40-year challenge to resolve clinical questions through experimental/laboratory techniques.Endocrine journal · 2025Article
- Sodium Chloride Cotransporter in Hypertension.Biomedicines · 2024Review
- Navigating the multifaceted intricacies of the NaPhysiological reviews · 2024Review
- Current perspective on circadian function of the kidney.American journal of physiology. Renal physiology · 2024Review
- The Intersection of Prostate Cancer and Hypertension: a Call to Action.Current treatment options in oncology · 2023Review
- Aldosterone: Renal Action and Physiological Effects.Comprehensive Physiology · 2023Article
- Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation.JCI insight · 2023Article
- In Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter.Kidney360 · 2022Article
- Circadian clocks of the kidney: function, mechanism, and regulation.Physiological reviews · 2022Review
- Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Kidney-specific KO of the circadian clock protein PER1 alters renal NaAmerican journal of physiology. Renal physiology · 2022Article
- Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.Comprehensive Physiology · 2021Review
- Circadian Control of Sodium and Blood Pressure Regulation.American journal of hypertension · 2021Review
- Soluble (Pro)Renin Receptor as a Negative Regulator of NCC (NaHypertension (Dallas, Tex. : 1979) · 2021Article
- Review
- Identifying new cellular mechanisms of mineralocorticoid receptor activation in the heart.Journal of human hypertension · 2021Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The sodium-chloride cotransporter (NCC) in the distal convoluted tubule contributes importantly to sodium balance and blood pressure (BP) regulation. NCC phosphorylation determines transport activity and has a diurnal rhythm influenced by glucocorticoids. Disturbing this rhythm induces "nondipping" BP, an abnormality that increases cardiovascular risk. The receptor through which glucocorticoids regulate NCC is not known. In this study, we found that acute administration of corticosterone to male C57BL6 mice doubled NCC phosphorylation without affecting total NCC abundance in both adrenalectomized and adrenal-intact mice. Corticosterone also increased the whole kidney expression of canonical clock genes: period circadian protein homolog 1 (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.