ArticleAnnals of clinical and translational neurology2019
Diffusion tensor imaging in orthostatic tremor: a tract-based spatial statistics study.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Increased susceptibility and volume reduction in deep brain nuclei in primary orthostatic tremor.BMJ neurology open · 2026Article
- White matter dysfunction in Alzheimer's disease is associated with disease-related transcriptomic signatures.Communications biology · 2025Article
- Cortical response to proprioceptive stimulation in primary orthostatic tremor - a magnetoencephalography study.Clinical neurophysiology practice · 2025Article
- Immediate and sustained effects of acupuncture on the default mode network.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Biomarkers and Rehabilitation for Functional Neurological Disorder.Journal of personalized medicine · 2024Review
- Mild hyperphenylalaninemia (hpa) presenting as orthostatic tremor: a case report.BMC neurology · 2022Article
- The Phenomenology of Primary Orthostatic Tremor.Movement disorders clinical practice · 2022Article
- Ataxia Prevalence in Primary Orthostatic Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- A data mining approach for classification of orthostatic and essential tremor based on MRI-derived brain volume and cortical thickness.Annals of clinical and translational neurology · 2019Article
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Authors and funding
7 authors at 7 institutions in 3 countries.
Funding
Abstract
objectiveThe pathogenesis of orthostatic tremor (OT) is unknown. We investigated OT-related white matter changes and their correlations with scores from a neuropsychological testing battery.
methodsDiffusion tensor imaging measures were compared between 14 OT patients and 14 age- and education-matched healthy controls, using whole-brain tract-based spatial statistics analysis. Correlations between altered diffusion metrics and cognitive performance in OT group were assessed.
resultsIn all cognitive domains (attention, executive function, visuospatial ability, verbal memory, visual memory, and language), OT patients' cognitive performance was significantly worse than that of healthy controls. OT patients demonstrated altered diffusivity metrics not only in the posterior lobe of the cerebellum (left cerebellar lobule VI) and in its efferent cerebellar fibers (left superior cerebellar peduncle), but also in medial lemniscus bilaterally (pontine tegmentum), anterior limb of the internal capsule bilaterally, right posterior limb of the internal capsule, left anterior corona radiata, right insula, and the splenium of corpus callosum. No relationship was found between diffusion measures and disease duration in OT patients. Diffusion white matter changes, mainly those located in right anterior limb of the internal capsule, were correlated with poor performance on tests of executive function, visuospatial ability, verbal memory, and visual memory in OT patients.
interpretationWhite matter changes were preferentially located in the cerebellum, its efferent pathways, as well as in the pontine tegmentum and key components of the frontal-thalamic-cerebellar circuit. Further work needs to be done to understand the evolution of these white matter changes and their functional consequences.
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