ArticleMolecular plant pathology2020
A revised model for the role of GacS/GacA in regulating type III secretion by Pseudomonas syringae pv. tomato DC3000.
Article in Molecular plant pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Motility and growth Burkholderia two-component: a new regulatory system of Burkholderia seminalis.Applied microbiology and biotechnology · 2026Article
- Novel insights into the genetic basis and transcriptomic elucidation of virulence attenuation inVirulence · 2025Article
- VimR is a conserved master transcription regulator controlling virulence and metabolism in Pseudomonas.Nucleic acids research · 2025Article
- Fostering plant protection against certain bacterial diseases through quorum-sensing signal molecules: a critical review.Frontiers in plant science · 2025Review
- Environmental alkalization suppresses deployment of virulence strategies inJournal of bacteriology · 2024Article
- Phaseolotoxin: Environmental Conditions and Regulatory Mechanisms Involved in Its Synthesis.Microorganisms · 2024Review
- GacA reduces virulence and increases competitiveness in planta in the tumorigenic olive pathogenFrontiers in plant science · 2024Article
- Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors.Engineering microbiology · 2023Review
- Article
- A putative multi-sensor hybrid histidine kinase, BarAFrontiers in microbiology · 2022Article
- Virulence-related regulatory network ofComputational and structural biotechnology journal · 2022Review
- The deletion of HK-1 gene affects the bacterial virulence of Pseudomonas stutzeri LH-42.PloS one · 2022Article
- Exploring the expression and functionality of theRNA biology · 2021Article
- Rapid evolution of bacterial mutualism in the plant rhizosphere.Nature communications · 2021Article
- Regulation of theMicroorganisms · 2021Review
- The Evanescent GacS Signal.Microorganisms · 2020Review
- Two Homologues of the Global Regulator Csr/Rsm Redundantly Control Phaseolotoxin Biosynthesis and Virulence in the Plant PathogenMicroorganisms · 2020Article
- Signal transduction schemes inComputational and structural biotechnology journal · 2020Review
- Re-evaluation of a Tn5::gacA mutant of Pseudomonas syringae pv. tomato DC3000 uncovers roles for uvrC and anmK in promoting virulence.PloS one · 2019Article
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5 authors.
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Abstract
GacS/GacA is a conserved two-component system that functions as a master regulator of virulence-associated traits in many bacterial pathogens, including Pseudomonas spp., that collectively infect both plant and animal hosts. Among many GacS/GacA-regulated traits, type III secretion of effector proteins into host cells plays a critical role in bacterial virulence. In the opportunistic plant and animal pathogen Pseudomonas aeruginosa, GacS/GacA negatively regulates the expression of type III secretion system (T3SS)-encoding genes. However, in the plant pathogenic bacterium Pseudomonas syringae, strain-to-strain variation exists in the requirement of GacS/GacA for T3SS deployment, and this variability has limited the development of predictive models of how GacS/GacA functions in this species. In this work we re-evaluated the function of GacA in P. syringae pv. tomato DC3000. Contrary to previous reports, we discovered that GacA negatively regulates the expression of T3SS genes in DC3000, and that GacA is not required for DC3000 virulence inside Arabidopsis leaf tissue. However, our results show that GacA is required for full virulence of leaf surface-inoculated bacteria. These data significantly revise current understanding of GacS/GacA in regulating P. syringae virulence.
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