ArticleTranslational vision science & technology2019
In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on
Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- Adjunctive povidone-iodine forAntimicrobial agents and chemotherapy · 2026Trial
- Nested PCR as a superior diagnostic method for Acanthamoeba keratitis compared to conventional techniques.Scientific reports · 2026Article
- The Rising Importance of Antiseptics in Ophthalmology: From Endophthalmitis Prevention to Treatment of Ocular Infections.Ophthalmology and therapy · 2025Review
- Pathogenesis and treatment strategies for infectious keratitis: Exploring antibiotics, antimicrobial peptides, nanotechnology, and emerging therapies.Journal of pharmaceutical analysis · 2025Review
- The Natural History of Acanthamoeba Keratitis: A Systematic Literature Review.Ophthalmology and therapy · 2025Review
- The Antimicrobial Efficacy of Amine-Containing Surfactants Against Cysts and Trophozoites ofMicroorganisms · 2025Article
- The pathogenesis, risk factors, diagnosis and treatment of Acanthamoeba keratitis.Frontiers in medicine · 2025Review
- Anti-adherent effects ofVeterinary world · 2024Article
- Understanding Acanthamoeba Keratitis: An In-Depth Review of a Sight-Threatening Eye Infection.Microorganisms · 2024Review
- Medicines for Malaria Venture Pandemic Box In Vitro Screening Identifies Compounds Highly Active against the Tachyzoite Stage ofTropical medicine and infectious disease · 2023Article
- Diagnosis ofDiagnostics (Basel, Switzerland) · 2023Review
- The Activity of PHMB and Other Guanidino Containing Compounds againstMicroorganisms · 2022Article
- Opportunistic free-living amoebal pathogens.Pathogens and global health · 2022Article
- Evaluation of Amebicidal and Cysticidal Activities of Antifungal Drug Isavuconazonium Sulfate againstPharmaceuticals (Basel, Switzerland) · 2021Article
- The Autofluorescence Patterns ofPathogens (Basel, Switzerland) · 2021Article
- The Effect of Anti-Amoebic Agents and Ce6-PDT onTranslational vision science & technology · 2020Article
- Discovery of Anti-Amoebic Inhibitors from Screening the MMV Pandemic Response Box onPathogens (Basel, Switzerland) · 2020Article
- Silver Nanoparticles as a Novel Potential Preventive Agent against Acanthamoeba Keratitis.Pathogens (Basel, Switzerland) · 2020Article
- In praise of povidone-iodine application in ophthalmology.Survey of ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the antimicrobial effect of topical anesthetics, antivirals, antibiotics, and biocides on the viability of
methodsAmoebicidal and cysticidal assays were performed against both trophozoites and cysts of
resultsProxymetacaine, oxybuprocaine, and especially tetracaine were all toxic to the trophozoites and cysts of
conclusionsThe antiamoebic effects of BAC, povidone iodine, and tetracaine are superior to the current diamidines and slightly inferior to the biguanides used in the treatment for TRANSLATIONAL RELEVANCE: Ophthalmologists should be aware that certain topical anesthetics and ophthalmic preparations containing BAC prior to specimen sampling may affect the viability of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.