ArticleTranslational vision science & technology2019
Comparative Study of Chemical Composition, Molecular and Rheological Properties of Silicone Oil Medical Devices.
Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Silicone oil tamponade in vitreoretinal surgery and future perspective: a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Complications of silicone oil in vitreoretinal surgery: a narrative review of clinical and experimental evidence.International journal of retina and vitreous · 2026Review
- A Novel Variable Volume Capillary Microgripper for Micromanipulation in Aqueous Media.Micromachines · 2025Article
- Large-scale synthesis of polydimethylsiloxane as vitreous replacement applications.Designed monomers and polymers · 2025Article
- A minimum specification dataset for liquid ocular endotamponades: recommendations by a European expert panel.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Vitreous Substitutes from Bench to the Operating Room in a Translational Approach: Review and Future Endeavors in Vitreoretinal Surgery.International journal of molecular sciences · 2023Review
- AlaFrontiers in pharmacology · 2023Article
- Retinal and Corneal Changes Associated with Intraocular Silicone Oil Tamponade.Journal of clinical medicine · 2022Review
- [Visual acuity reduction and silicone oil tamponade].Die Ophthalmologie · 2022Review
- Silicone oil versus gas tamponade for primary rhegmatogenous retinal detachment treated successfully with a propensity score analysis: Japan Retinal Detachment Registry.The British journal of ophthalmology · 2022Article
- Long-Term Reduction of Bacterial Adhesion on Polyurethane by an Ultra-Thin Surface Modifier.Biomedicines · 2022Article
- What Is the Cause of Toxicity of Silicone Oil?Materials (Basel, Switzerland) · 2021Article
- Biocompatibility of intraocular liquid tamponade agents: an update.Eye (London, England) · 2021Review
- Silicone oil safety is not only a purity question.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Silicone oils compared and found wanting.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Silicone oil complications in vitreoretinal surgery.Romanian journal of ophthalmologyObservational
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe evaluated chemical composition, and molecular and rheological properties in 10 commercially available silicone oils (SilOils), focusing on siloxane chains of low molecular weight (LMW components, LMWC) that are known to be "impurities" produced during the SilOil synthesis process.
methodsWe assessed the type of SilOil polymer and molecular weight distribution (MWD) by spectroscopy and conventional size exclusion chromatography, respectively. From the Cumulative MWD, we calculated the fractions of LMWC with molecular weight (M): ≤2000, ≤5000, and ≤10,000 g/mol. Due to the low MW, the content of LMWC with M ≤1000 g/mol was determined by gas chromatography-mass spectrometry. The dynamic viscosity (η) was assessed by rotational rheometry.
resultsFor all SilOils, the polymer was polydimethylsiloxane. The samples differed significantly in terms of MWD and relative LMWC fractions. Specifically, the relative fraction of all LMWC (M ≤10,000 g/mol) ranged from 2.31% to 9.40% and the content of LMWC with M ≤1000 g/mol also varied significantly (range, 51-1151 ppm). The η values were different between the SilOils, and, for many of them, from the declared viscosity.
conclusionsCommercially available SilOils differ significantly in molecular and rheologic features. These compounds contain a significant amount of LMWC, "impurities" generated during the synthesis process, acting as emulsifier, potentially inducing ocular inflammation and toxicity. TRANSLATIONAL RELEVANCE: The amount of impurities in different SilOils may influence significantly their biocompatibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.