ArticleBone & joint research2019
Tendon-derived stem cells from the long head of the biceps tendon: Inflammation does not affect the regenerative potential.
Article in Bone & joint research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Open-Book Technique With Sliced Biceps Tendon Autograft Augmentation in the Reconstruction of the Subscapularis in Shoulder Arthroplasty.Arthroscopy techniques · 2025Article
- Acellular porcine Achilles tendon patch encapsulating tendon-derived stem cells for rotator cuff repair in a rabbit model.Scientific reports · 2024Article
- Rotator cuff tears.Nature reviews. Disease primers · 2024Review
- Subscapularis Repair Augmentation With the Long Head Biceps Tendon During Anatomic Total Shoulder Arthroplasty: The "Biceps-Subscap Sling" Technique.Arthroscopy techniques · 2023Article
- [Progress and prospect of biological treatment for rotator cuff injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Review
- Arthroscopic repair of massive rotator cuff tear. The role of the LHB distal tenotomy.Musculoskeletal surgery · 2022Article
- Characterization of Tendon-Derived Stem Cells and Rescue Tendon Injury.Stem cell reviews and reports · 2021Review
- Current Biological Strategies to Enhance Surgical Treatment for Rotator Cuff Repair.Frontiers in bioengineering and biotechnology · 2021Review
- Rejuvenated ageing mesenchymal stem cells by stepwise preconditioning ameliorates surgery-induced osteoarthritis in rabbits.Bone & joint research · 2021Article
- Superior Capsular Reconstruction With Double Bundle of Long Head Biceps Tendon Autograft: The "Box" Technique.Arthroscopy techniques · 2020Article
- The importance of plasmin for the healing of the anterior cruciate ligament.Bone & joint research · 2020Article
- Arthroscopic Rotator Cuff Repair Reinforced With Proximal Biceps Rerouting.Video journal of sports medicineArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe long head of the biceps (LHB) is often resected in shoulder surgery and could therefore serve as a cell source for tissue engineering approaches in the shoulder. However, whether it represents a suitable cell source for regenerative approaches, both in the inflamed and non-inflamed states, remains unclear. In the present study, inflamed and native human LHBs were comparatively characterized for features of regeneration.
methodsIn total, 22 resected LHB tendons were classified into inflamed samples (n = 11) and non-inflamed samples (n = 11). Proliferation potential and specific marker gene expression of primary LHB-derived cell cultures were analyzed. Multipotentiality, including osteogenic, adipogenic, chondrogenic, and tenogenic differentiation potential of both groups were compared under respective lineage-specific culture conditions.
resultsInflammation does not seem to affect the proliferation rate of the isolated tendon-derived stem cells (TDSCs) and the tenogenic marker gene expression. Cells from both groups showed an equivalent osteogenic, adipogenic, chondrogenic and tenogenic differentiation potential in histology and real-time polymerase chain reaction (RT-PCR) analysis.
conclusionThese results suggest that the LHB tendon might be a suitable cell source for regenerative approaches, both in inflamed and non-inflamed states. The LHB with and without tendinitis has been characterized as a novel source of TDSCs, which might facilitate treatment of degeneration and induction of regeneration in shoulder surgery.
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