Evidence map›Paper›PMID 31588354›Full record

ReviewF1000Research2019

Recent advances in understanding the role of phasic dopamine activity.

Wolfram Schultz

Abstract readReview
In one paragraph

Review in F1000Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Prior novelty invigorates future mesolimbic target detection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Prior Novelty Invigorates Future Mesolimbic Target Detection.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Inhibition of Dopamine Neurons Prevents Incentive Value Encoding of a Reward Cue: With Revelations from Deep Phenotyping.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  13. Review
  14. Striatal dopamine in anhedonia: A simultaneous [Psychiatry research. Neuroimaging · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Wolfram SchultzDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK.ORCID 0000-0002-8530-4518

Funding

Wellcome TrustWellcome Trust 204811/Z/16/ZWellcome Trust WT 204811
6 · The paper itself

Abstract

The latest animal neurophysiology has revealed that the dopamine reward prediction error signal drives neuronal learning in addition to behavioral learning and reflects subjective reward representations beyond explicit contingency. The signal complies with formal economic concepts and functions in real-world consumer choice and social interaction. An early response component is influenced by physical impact, reward environment, and novelty but does not fully code prediction error. Some dopamine neurons are activated by aversive stimuli, which may reflect physical stimulus impact or true aversiveness, but they do not seem to code general negative value or aversive prediction error. The reward prediction error signal is complemented by distinct, heterogeneous, smaller and slower changes reflecting sensory and motor contributors to behavioral activation, such as substantial movement (as opposed to precise motor control), reward expectation, spatial choice, vigor, and motivation. The different dopamine signals seem to defy a simple unifying concept and should be distinguished to better understand phasic dopamine functions.

Indexed as

RewardAnimalsDopamineDopaminergic NeuronsLearningMotivationDopamineaversivelearningmovementpredictionreward

Identifiers

PMID31588354
PMCPMC6760455

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.