ArticleChemical science2019
Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Palladium-catalyzed enantioselective alkenylation of acyclic alkenols: Broad scope with alkenyl bromides.Science advances · 2026Article
- The Role of 1,2-Palladium Migration/Insertion on C(spACS organic & inorganic Au · 2025Review
- Immobilization of Trifluoromethyl-Substituted Pyridine-Oxazoline Ligand and Its Application in Asymmetric Continuous Flow Synthesis of Benzosultams.The Journal of organic chemistry · 2023Article
- Enantioselective Hydroalkenylation and Hydroalkynylation of Alkenes Enabled by a Transient Directing Group: Catalyst Generality through Rigidification.Angewandte Chemie (International ed. in English) · 2023Article
- Rate Profiling the Impact of Remote Functional Groups on the Redox-Relay Heck Reaction.Organic letters · 2021Article
- Stereoselective Remote Functionalization via Palladium-Catalyzed Redox-Relay Heck Methodologies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Enantioselective Synthesis of γ-Functionalized Cyclopentenones and δ-Functionalized Cycloheptenones Utilizing a Redox-Relay Heck Strategy.Advanced synthesis & catalysis · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A regioselective and enantioselective palladium-catalyzed relay Heck alkenylation of alkenylbenzene derivatives to construct remote stereocenters is disclosed. Various β-substituted styrenes were readily obtained in moderate yields with good to excellent levels of enantioselectivity. This strategy provides rapid access to enantioenriched δ, ε, ζ, and η-alkenyl aryl compounds from simple starting materials. Mechanistic studies suggest that termination of the relay reaction is controlled by affinity of the arene for the Pd complex during migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.