Evidence map›Paper›PMID 31588290›Full record

ArticleChemical science2019

A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging.

Rongchen Wang, Jian Chen, Jie Gao, Ji-An Chen, Ge Xu, Tianli Zhu, Xianfeng Gu, Zhiqian Guo, Wei-Hong Zhu, Chunchang Zhao

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 161 citations in OpenAlex.

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  14. Enzyme-activated probes in optical imaging: a focus on atherosclerosis.Dalton transactions (Cambridge, England : 2003) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Rongchen WangKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center , Institute of Fine Chemicals , School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai , 200237 , P. R. China . Email: zhaocchang@ecust.edu.cn.
Jian ChenKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center , Institute of Fine Chemicals , School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai , 200237 , P. R. China . Email: zhaocchang@ecust.edu.cn.
Jie GaoDepartment of Medicinal Chemistry , School of Pharmacy , Fudan University , Shanghai , 201203 , P. R. China.
Ji-An ChenDepartment of Medicinal Chemistry , School of Pharmacy , Fudan University , Shanghai , 201203 , P. R. China.
Ge XuKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center , Institute of Fine Chemicals , School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai , 200237 , P. R. China . Email: zhaocchang@ecust.edu.cn.
Tianli ZhuKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center , Institute of Fine Chemicals , School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai , 200237 , P. R. China . Email: zhaocchang@ecust.edu.cn.
Xianfeng GuDepartment of Medicinal Chemistry , School of Pharmacy , Fudan University , Shanghai , 201203 , P. R. China.ORCID 0000-0002-7462-7266
Zhiqian GuoKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center , Institute of Fine Chemicals , School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai , 200237 , P. R. China . Email: zhaocchang@ecust.edu.cn.ORCID 0000-0002-2192-825X
Wei-Hong ZhuKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center , Institute of Fine Chemicals , School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai , 200237 , P. R. China . Email: zhaocchang@ecust.edu.cn.ORCID 0000-0001-9103-166X
Chunchang ZhaoKey Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center , Institute of Fine Chemicals , School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai , 200237 , P. R. China . Email: zhaocchang@ecust.edu.cn.ORCID 0000-0003-2952-7036
East China University of Science and Technology · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advance of cancer imaging requires innovations to establish novel fluorescent scaffolds that are excitable and emit in the near-infrared region with favorable Stokes shifts. Nevertheless, the lack of probes with these optimized optical properties presents a major bottleneck in targeted cancer imaging. By coupling of boron dipyrromethene platforms to enzymic substrates

Identifiers

PMID31588290
PMCPMC6677112
OpenAlexW2950294497

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.