Evidence map›Paper›PMID 31588266›Full record

ArticleChemical science2019

Unveiling the metabolic fate of monosaccharides in cell membranes with glycomic and glycoproteomic analyses.

Gege Xu, Maurice Wong, Qiongyu Li, Dayoung Park, Zhi Cheng, Carlito B Lebrilla

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Laser cleavable probes forChemical science · 2019
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gege XuDepartment of Chemistry , University of California , One Shields Avenue Davis , Davis , CA 95616 , USA . Email: cblebrilla@ucdavis.edu.ORCID 0000-0002-0792-2636
Maurice WongDepartment of Chemistry , University of California , One Shields Avenue Davis , Davis , CA 95616 , USA . Email: cblebrilla@ucdavis.edu.
Qiongyu LiDepartment of Chemistry , University of California , One Shields Avenue Davis , Davis , CA 95616 , USA . Email: cblebrilla@ucdavis.edu.ORCID 0000-0003-3654-0378
Dayoung ParkDepartment of Chemistry , University of California , One Shields Avenue Davis , Davis , CA 95616 , USA . Email: cblebrilla@ucdavis.edu.ORCID 0000-0003-4983-4340
Zhi ChengDepartment of Chemistry , University of California , One Shields Avenue Davis , Davis , CA 95616 , USA . Email: cblebrilla@ucdavis.edu.
Carlito B LebrillaDepartment of Chemistry , University of California , One Shields Avenue Davis , Davis , CA 95616 , USA . Email: cblebrilla@ucdavis.edu.
University of California System · US

Funding

The incorporation of human milk oligosaccharides in brain glycoconjugatesR01GM049077 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEBRILLA, CARLITO B · 1999 to 2024
$6.3M
Comprehensive Characterization of Glycosylation Alterations in Alzheimer’s DiseaseR01AG062240 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JIN, LEE-WAY, LEBRILLA, CARLITO B · 2018 to 2022
$3.3M
NIA NIH HHS R01 AG062240NIGMS NIH HHS R01 GM049077
6 · The paper itself

Abstract

Cell membrane protein glycosylation is dependent on the metabolic state of the cell as well as exogenous nutrients available. Although the metabolism and interconversion of monosaccharides have been well-studied, their incorporation into cell surface glycans and their corresponding glycoproteins remains relatively unknown. In this study, we developed a method to investigate quantitatively the incorporation pathways of dietary saccharides into specific glycans and glycoproteins on the cell membrane by treating intestinal Caco-2 and hepatic KKU-M213 cells with

Identifiers

PMID31588266
PMCPMC6676465
OpenAlexW2951667965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.