Evidence map›Paper›PMID 31588204›Full record

ArticleAdvanced functional materials2018

Development of Citrate-based Dual-Imaging Enabled Biodegradable Electroactive Polymers.

Dingying Shan, Sri-Rajasekhar Kothapalli, Dino J Ravnic, Ethan Gerhard, Jimin P Kim, Jinshan Guo, Chuying Ma, Jiazhi Guo, Li Gui, Lin Sun and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Development of Biodegradable Osteopromotive Citrate-Based Bone Putty.Small (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Multifunctional CuBiSFrontiers in bioengineering and biotechnology · 2020
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Dingying ShanDepartment of Biomedical Engineering; Materials Research Institute; The Huck Institutes of The Life Sciences The Pennsylvania State University, University Park, PA, 16802, USA.
Sri-Rajasekhar KothapalliDepartment of Biomedical Engineering The Pennsylvania State University, University Park, PA 16802, USA; Penn State Hershey Cancer Institute Hershey, PA 17033, USA.
Dino J RavnicDepartment of Surgery Penn State Hershey Medical Center, Hershey, PA, 17033, USA.
Ethan GerhardDepartment of Biomedical Engineering; Materials Research Institute; The Huck Institutes of The Life Sciences The Pennsylvania State University, University Park, PA, 16802, USA.
Jimin P KimDepartment of Biomedical Engineering; Materials Research Institute; The Huck Institutes of The Life Sciences The Pennsylvania State University, University Park, PA, 16802, USA.
Jinshan GuoDepartment of Biomedical Engineering; Materials Research Institute; The Huck Institutes of The Life Sciences The Pennsylvania State University, University Park, PA, 16802, USA.
Chuying MaDepartment of Biomedical Engineering; Materials Research Institute; The Huck Institutes of The Life Sciences The Pennsylvania State University, University Park, PA, 16802, USA.
Jiazhi GuoBiomedical Engineering Research Center Kunming Medical University, Kunming, 650500, China.
Li GuiDepartment of Endocrinology The Third People's Hospital of Yunnan Province, Kunming 650011, China.
Lin SunDepartment of Cardiology The Second Affiliated Hospital, Kunming Medical University, Kunming 650101, China.
Di LuBiomedical Engineering Research Center Kunming Medical University, Kunming, 650500, China.
Jian YangDepartment of Biomedical Engineering; Materials Research Institute; The Huck Institutes of The Life Sciences The Pennsylvania State University, University Park, PA, 16802, USA.
Pennsylvania State University · USKunming Medical University · CNPenn State Milton S. Hershey Medical Center · USKunming University · CNThird People's Hospital of Yunnan Province · CN

Funding

Citrate Metabonegenic Regulation for the next Generation of Orthopedic Biomaterial DesignR01AR072731 · NIAMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI YANG, JIAN · 2018 to 2022
$1.7M
Developing targeted therapy with prostate cancer specific nanomedicineR01CA182670 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HSIEH, JER-TSONG, YANG, JIAN · 2013 to 2017
$1.6M
Transrectal Ultrasound and Photoacoustic Imagining of Prostate and Molecular ImagR00EB017729 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI KOTHAPALLI, SRI RAJASEKHAR · 2017 to 2019
$723k
Chromatic two-photon fluorescence microsopy using band-shifting imaging probesR21EB024829 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI LIU, ZHIWEN, YANG, JIAN · 2017 to 2018
$410k
NCI NIH HHS R01 CA182670NIAMS NIH HHS R01 AR072731NIBIB NIH HHS R00 EB017729NIBIB NIH HHS R21 EB024829
6 · The paper itself

Abstract

Increasing occurrences of degenerative diseases, defective tissues and severe cancers heighten the importance of advanced biomedical treatments, which in turn enhance the need for improved biomaterials with versatile theranostic functionalities yet using minimal design complexity. Leveraging the advantages of citrate chemistry, we developed a multifunctional citrate-based biomaterial platform with both imaging and therapeutic capabilities utilizing a facile and efficient one-pot synthesis. The resulting aniline tetramer doped biodegradable photoluminescent polymers (BPLPATs) not only possess programmable degradation profiles (<1 to >6 months) and mechanical strengths (~20 MPa to > 400 MPa), but also present a combination of intrinsic fluorescence, photoacoustic (PA) and electrical conductivity properties. BPLPAT nanoparticles are able to label cells for fluorescence imaging and perform deep tissue detection with PA imaging. Coupled with significant photothermal performance, BPLPAT nanoparticles demonstrate great potential for thermal treatment and

Indexed as

citrateconductive polymersdegradationfluorescencephotoacoustic

Identifiers

PMID31588204
PMCPMC6777557
OpenAlexW2810561059

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.