Evidence map›Paper›PMID 31588171›Full record

ArticleHuman and ecological risk assessment : HERA2018

Application of a novel mass spectrometric (MS) method to examine exposure to Bisphenol-A and common substitutes in a maternal fetal cohort.

Erin Speiser Ihde, Stacy Zamudio, Ji Meng Loh, Yalin Zhu, John Woytanowski, Lawrence Rosen, Min Liu, Brian Buckley

Open access · hybridAbstract read
In one paragraph

Article in Human and ecological risk assessment : HERA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Erin Speiser IhdeThe Deirdre Imus Environmental Health Center®, Hackensack University Medical Center, 30 Prospect Ave, Research Building, Hackensack NJ 07601, USA.
Stacy ZamudioDepartment of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine and Surgery, Hackensack University Medical Center, 30 Prospect Ave, Hackensack NJ 07601, USA.
Ji Meng LohDept. of Mathematical Sciences, NJ Institute of Technology, University Heights, Newark, NJ 07102, USA.
Yalin ZhuDept. of Mathematical Sciences, NJ Institute of Technology, University Heights, Newark, NJ 07102, USA.
John WoytanowskiSt. George's University School of Medicine, Grenada, West Indies.
Lawrence RosenThe Deirdre Imus Environmental Health Center®, Hackensack University Medical Center, 30 Prospect Ave, Research Building, Hackensack NJ 07601, USA.
Min LiuEnvironmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ08854, USA.
Brian BuckleyEnvironmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ08854, USA.
Hackensack University Medical Center · USNew Jersey Institute of Technology · USRutgers, The State University of New Jersey · USSt. George's University · GD

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI ROBERT John LAUMBACH · 1988 to 2026
$47.4M
NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

The use of Bisphenol A (BPA) has widely been replaced in consumer products by analogs BPB, BPE, BPF, BPS, and BPAF. Recent studies have linked these substitutes to similar adverse health outcomes as BPA, including disruption of endocrine pathways in animal and human studies. We designed a novel MS method, developed specifically for this study, to capture the most relevant BPA alternatives, BPB, BPE, BPF, BPS, BPAF and 4-NP in human blood and urine to quantify potential in utero exposures. To our knowledge, this is the first study to explore in utero exposure to these BPA analogs and the first U.S. study to test for BPA in maternal/fetal pairs. The method was run on 30 paired maternal urine and fetal cord blood samples from mothers undergoing elective Caesarean sections. 90% of mothers and 77% of babies tested positive for at least one BP analog. 83% of mothers tested positive for BPAF, 60% for BPS, 57% for BPB, 17% for BPF and 7% for BPA. 57% of babies tested positive for BPAF and 50% for BPF. BPA and BPB were detected in one cord blood sample each. BPS was not detected in cord blood. BPE was not detected in any fetal cord blood or maternal urine samples. These findings demonstrate the pervasiveness of some BP analogs in pregnant women and their babies at birth.

Indexed as

bisphenolBPABPAFBPBBPEBPFBPSendocrine disruptionfetal

Identifiers

PMID31588171
PMCPMC6777866
OpenAlexW2756694471

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.