Evidence map›Paper›PMID 31588165›Full record

ArticleJournal of micromechanics and microengineering : structures, devices, and systems2017

Mixing high-viscosity fluids via acoustically driven bubbles.

Sinem Orbay, Adem Ozcelik, James Lata, Murat Kaynak, Mengxi Wu, Tony Jun Huang

Open access · greenAbstract read
In one paragraph

Article in Journal of micromechanics and microengineering : structures, devices, and systems, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Open source acoustofluidics.Lab on a chip · 2019
    Article
  13. Article
  14. Acoustic Actuation ofJournal of micromechanics and microengineering : structures, devices, and systems · 2018
    Article
  15. A Review on Micromixers.Micromachines · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sinem OrbayDepartment of Biomedical Engineering, The Pennsylvania State University, University park, PA 16802, USA.
Adem OzcelikDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University park, PA 16802, USA.
James LataDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University park, PA 16802, USA.
Murat KaynakDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University park, PA 16802, USA.
Mengxi WuDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University park, PA 16802, USA.
Tony Jun HuangDepartment of Biomedical Engineering, The Pennsylvania State University, University park, PA 16802, USA.
Pennsylvania State University · US

Funding

Standing Surface Acoustic Wave Based Cell Sorters for Maintaining Cell IntegrityR01GM112048 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, TONY JUN · 2014 to 2017
$1.1M
Validation of acoustic tweezers for single-cell analyses of purine metabolismR33EB019785 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, TONY JUN · 2014 to 2016
$1.1M
NIBIB NIH HHS R33 EB019785NIGMS NIH HHS R01 GM112048
6 · The paper itself

Abstract

We present an acoustofluidic micromixer which can perform rapid and homogeneous mixing of highly viscous fluids in the presence of an acoustic field. In this device, two high-viscosity polyethylene glycol (PEG) solutions were co-injected into a three-inlet PDMS microchannel with the center inlet containing a constant stream of nitrogen flow which forms bubbles in the device. When these bubbles were excited by an acoustic field generated via a piezoelectric transducer, the two solutions mixed homogenously due to the combination of acoustic streaming, droplet ejection, and bubble eruption effects. The mixing efficiency of this acoustofluidic device was evaluated using PEG-700 solutions which are ~106 times more viscous than deionized (DI) water. Our results indicate homogenous mixing of the PEG-700 solutions with a ~0.93 mixing index. The acoustofluidic micromixer is compact, inexpensive, easy to operate, and has the capacity to mix highly viscous fluids within 50 milliseconds.

Indexed as

acoustofluidicshigh-viscosity fluidMicromixingpolyethylene glycol (PEG)

Identifiers

PMID31588165
PMCPMC6777744
OpenAlexW2540816893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.