ArticleCell chemical biology2019
Family-wide Annotation of Enzymatic Pathways by Parallel In Vivo Metabolomics.
Article in Cell chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Tissue-dependent enzymatic control of N-acetyl-β-alanine by PTER.The Journal of biological chemistry · 2026Article
- Unveiling Plant Metabolic Diversity: Integrating Metabolomics with Multi-Omics Approaches for Crop Improvement.Plants (Basel, Switzerland) · 2026Review
- Beyond exercise and appetite: The expanding biology and therapeutic potential of N-lactoyl-phenylalanine.The Journal of pharmacology and experimental therapeutics · 2026Review
- Carnosine Dipeptidase(Cndp): An emerging therapeutic target for metabolic diseases and cancers.Genes & diseases · 2026Review
- Article
- "Shunt-ing" down obesity with novel endogenous metabolites.Cell metabolism · 2025Article
- Proteomic Analysis Is Needed to Understand the Vulnerability ofJournal of proteome research · 2025Article
- CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases?Journal of cardiovascular translational research · 2025Review
- Article
- Lac-Phe (N-lactoyl-phenylalanine).Trends in endocrinology and metabolism: TEM · 2024Article
- Lac-Phe mediates the effects of metformin on food intake and body weight.Nature metabolism · 2024Article
- Metformin induces a Lac-Phe gut-brain signalling axis.Nature metabolism · 2024Article
- A PTER-dependent pathway of taurine metabolism linked to energy balance.bioRxiv : the preprint server for biology · 2024Article
- Hallmarks of the metabolic secretome.Trends in endocrinology and metabolism: TEM · 2024Review
- Lac-Phe mediates the anti-obesity effect of metformin.bioRxiv : the preprint server for biology · 2023Article
- Ultra-high-performance liquid chromatography high-resolution mass spectrometry variants for metabolomics research.Nature methods · 2021Review
- Identification and Validation of Novel Serum Autoantibodies Biomarkers for Staging Liver Fibrosis in Patients With Chronic Hepatitis B.Frontiers in medicine · 2021Article
- A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity.Cell chemical biology · 2020Article
- Super-enhancer-driven metabolic reprogramming promotes cystogenesis in autosomal dominant polycystic kidney disease.Nature metabolism · 2020Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Enzymes catalyze fundamental biochemical reactions that control cellular and organismal homeostasis. Here we present an approach for de novo biochemical pathway discovery across entire mammalian enzyme families using parallel viral transduction in mice and untargeted liquid chromatography-mass spectrometry. Applying this method to the M20 peptidases uncovers both known pathways of amino acid metabolism as well as a previously unknown CNDP2-regulated pathway for threonyl dipeptide catabolism. Ablation of CNDP2 in mice elevates threonyl dipeptides across multiple tissues, establishing the physiologic relevance of our biochemical assignments. Taken together, these data underscore the utility of parallel in vivo metabolomics for the family-wide discovery of enzymatic pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.