ArticleNeuron2019
Orofacial Movements Involve Parallel Corticobulbar Projections from Motor Cortex to Trigeminal Premotor Nuclei.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Oral somatosensation shapes lingual muscle maps in macaque orofacial primary motor cortex.bioRxiv : the preprint server for biology · 2026Article
- Opioid- and NMDA-receptor-dependent neural plasticity mediates long-term analgesia from motor cortical stimulation.bioRxiv : the preprint server for biology · 2026Article
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
- Article
- Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement.Nature communications · 2026Article
- Multi-area activity in mouse motor cortex associated with one- and two-handed oromanual dexterity.bioRxiv : the preprint server for biology · 2026Article
- Corticothalamic communication for action coordination in a skilled motor behavior.Nature neuroscience · 2026Article
- Advances in research on dental occlusion and brain function: neuroimaging correlates and molecular mechanisms.Frontiers in neurology · 2026Review
- Artificial Intelligence-Driven Hemodynamic Monitoring of Simulated Bruxism Using Functional Near-Infrared Spectroscopy: A Preliminary Study.CNS neuroscience & therapeutics · 2025Article
- Multiple cortical systems influence a single vibrissa muscle.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hand-Jaw Coordination as Mice Handle Food Is Organized around Intrinsic Structure-Function Relationships.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Optogenetics in oral and craniofacial research.Journal of Zhejiang University. Science. B · 2024Review
- Low- and high-level coordination of orofacial motor actions.Current opinion in neurobiology · 2023Review
- Article
- Layer 5 Intratelencephalic Neurons in the Motor Cortex Stably Encode Skilled Movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Manipulation-specific cortical activity as mice handle food.Current biology : CB · 2022Article
- Mapping the vocal circuitry of Alston's singing mouse with pseudorabies virus.The Journal of comparative neurology · 2022Article
- Networking brainstem and basal ganglia circuits for movement.Nature reviews. Neuroscience · 2022Review
- Secondary thalamic neuroinflammation after focal cortical stroke and traumatic injury mirrors corticothalamic functional connectivity.The Journal of comparative neurology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
How do neurons in orofacial motor cortex (MCtx) orchestrate behaviors? We show that focal activation of MCtx corticobulbar neurons evokes behaviorally relevant concurrent movements of the forelimb, jaw, nose, and vibrissae. The projections from different locations in MCtx form gradients of boutons across premotor nuclei spinal trigeminal pars oralis (SpVO) and interpolaris rostralis (SpVIr). Furthermore, retrograde viral tracing from muscles that control orofacial actions shows that these premotor nuclei segregate their outputs. In the most dramatic case, both SpVO and SpVIr are premotor to forelimb and vibrissa muscles, while only SpVO is premotor to jaw muscles. Functional confirmation of the superimposed control by MCtx was obtained through selective optogenetic activation of corticobulbar neurons on the basis of their preferential projections to SpVO versus SpVIr. We conclude that neighboring projection neurons in orofacial MCtx form parallel pathways to distinct pools of trigeminal premotor neurons that coordinate motor actions into a behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.