ArticleCell2019
Peptidoglycan Production by an Insect-Bacterial Mosaic.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 107 citations in OpenAlex.
- Cellular remodeling of ovarian follicular epithelial cells transmits an obligate nutritional endosymbiont in a scale insect.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Convergent extreme reductive evolution in ancient planthopper symbioses.Nature communications · 2026Article
- Genome degradation results in nested symbiosis and endosymbiont replacement in cicadas.Nature communications · 2025Article
- Genomic Evolution and Patterns of Horizontal Gene Transfer in Coccomorpha Species.Ecology and evolution · 2025Article
- Origin and function of beneficial bacterial symbioses in insects.Nature reviews. Microbiology · 2025Review
- Protein import into bacterial endosymbionts and evolving organelles.The FEBS journal · 2025Review
- A nucleus-encoded dynamin-like protein controls endosymbiont division in the trypanosomatidScience advances · 2025Article
- Cooperation between symbiotic partners through protein trafficking.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A complete DNA repair system assembled by two endosymbionts restores heat tolerance of the insect host.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genetic potential for aerobic respiration and denitrification in globally distributed respiratory endosymbionts.Nature communications · 2024Article
- Facultatively intrabacterial localization of a planthopper endosymbiont as an adaptation to its vertical transmission.mSystems · 2024Article
- Endosymbioses Have Shaped the Evolution of Biological Diversity and Complexity Time and Time Again.Genome biology and evolution · 2024Review
- Retention of an Endosymbiont for the Production of a Single Molecule.Genome biology and evolution · 2024Article
- How do bacterial endosymbionts work with so few genes?PLoS biology · 2024Article
- Phenazine biosynthesis protein MoPhzF regulates appressorium formation and host infection through canonical metabolic and noncanonical signaling function in Magnaporthe oryzae.The New phytologist · 2024Article
- Combating multidrug-resistance inNAR molecular medicine · 2024Article
- Evolutionary history of tyrosine-supplementing endosymbionts in pollen-feeding beetles.The ISME journal · 2024Article
- Article
- The nutritional dimension of facultative bacterial symbiosis in aphids: Current status and methodological considerations for future research.Current research in insect science · 2024Review
- Widespread horizontal gene transfer between plants and bacteria.ISME communications · 2024Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Peptidoglycan (PG) is a defining feature of bacteria, involved in cell division, shape, and integrity. We previously reported that several genes related to PG biosynthesis were horizontally transferred from bacteria to the nuclear genome of mealybugs. Mealybugs are notable for containing a nested bacteria-within-bacterium endosymbiotic structure in specialized insect cells, where one bacterium, Moranella, lives in the cytoplasm of another bacterium, Tremblaya. Here we show that horizontally transferred genes on the mealybug genome work together with genes retained on the Moranella genome to produce a PG layer exclusively at the Moranella cell periphery. Furthermore, we show that an insect protein encoded by a horizontally transferred gene of bacterial origin is transported into the Moranella cytoplasm. These results provide a striking parallel to the genetic and biochemical mosaicism found in organelles, and prove that multiple horizontally transferred genes can become integrated into a functional pathway distributed between animal and bacterial endosymbiont genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.