Evidence map›Paper›PMID 31587826›Full record

ArticleBiophysical journal2019

Exploring the Nature of Cationic Blocker Recognition by the Anthrax Toxin Channel.

Sanaz Momben Abolfath, Michelle Kolberg, Vladimir A Karginov, Stephen H Leppla, Ekaterina M Nestorovich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Protein Ligand-Induced Amplification in the 1/Langmuir : the ACS journal of surfaces and colloids · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sanaz Momben AbolfathDepartment of Biology, The Catholic University of America, Washington DC.
Michelle KolbergDepartment of Biology, The Catholic University of America, Washington DC.
Vladimir A KarginovKFBio LLC, Ashburn, Virginia.
Stephen H LepplaLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Ekaterina M NestorovichDepartment of Biology, The Catholic University of America, Washington DC. Electronic address: nestorovich@cua.edu.

Funding

OBSTRUCTING TOXIN'S PATHWAYS: UNIVERSAL INHIBITORS OF BINARY BACTERIAL TOXINSR15AI099897 · NIAID · CATHOLIC UNIVERSITY OF AMERICA · PI NESTOROVICH, EKATERINA · 2014 to 2014
$423k
NIAID NIH HHS R15 AI099897
6 · The paper itself

Abstract

Obstructing conductive pathways of the channel-forming toxins with targeted blockers is a promising drug design approach. Nearly all tested positively charged ligands have been shown to reversibly block the cation-selective channel-forming protective antigen (PA

Indexed as

Antigens, BacterialBacterial Toxinsbeta-CyclodextrinsCationsDendrimersKineticsOnium CompoundsTime FactorsTriphenylmethyl Compoundsanthrax toxinAntigens, BacterialBacterial Toxinsbeta-CyclodextrinsbetadexCationsDendrimersOnium CompoundsPAMAM StarburstTriphenylmethyl Compoundstriphenylmethylphosphonium

Identifiers

PMID31587826
PMCPMC6838753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.