ReviewEpidemiology and infection2019
Diagnosis of spotted fever group
Review in Epidemiology and infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 101 citations in OpenAlex.
- Development of chimeric monoclonal antibodies as standardised positive controls in rickettsial serodiagnosis.Scientific reports · 2026Article
- Neglected rickettsial diseases in Southeast Asia: Twenty-five years of progress in surveillance, diagnostics, and clinical research.PLoS neglected tropical diseases · 2026Review
- Molecular Detection and Identification of Bacterial Pathogens in Qinghai Province, China.Pathogens (Basel, Switzerland) · 2026Article
- Simultaneous serological assessment of four zoonotic rickettsiae among dogs near the United States-Mexico border.PLoS neglected tropical diseases · 2026Article
- High fever with rash: a case report of spotted fever group rickettsial infection at a construction site.BMC infectious diseases · 2026Article
- First molecularly-confirmed canine rickettsiosis in Southern Philippines (Cebu): A case report.Open veterinary journal · 2026Article
- Targeting surface cell antigen 2 increases sensitivity of Rickettsia typhi detection.PLoS neglected tropical diseases · 2026Article
- Seasonal and spatial trends of rickettsioses in Sri Lanka (2009-2023): Spatio-temporal analysis and climate-linked modeling.PloS one · 2026Article
- Bridging historical antigenic profiling and whole-genome taxonomy inScientific reviews · 2026Review
- Development of a Novel Sandwich ELISA Test for the Detection of Antibodies Against Rickettsia.Pathogens (Basel, Switzerland) · 2025Article
- The use of tNGS in the diagnosis of Q fever: A case report and review of cases of liver injury.Infectious medicine · 2025Article
- Human infection with Candidatus Rickettsia jingxinensis: First identification and clinical characteristics.PLoS neglected tropical diseases · 2025Article
- Prevalence and risk factors for murine typhus, scrub typhus and spotted fever group rickettsioses among adolescent and adult patients presenting to Yangon General Hospital, Yangon, Myanmar.Tropical medicine & international health : TM & IH · 2025Article
- Roles of tick-cofeeding hedgehogs in the natural transmission of spotted fever group Rickettsia.PLoS neglected tropical diseases · 2025Article
- Tick-Borne Infectious Diseases in China, 2003-2023.China CDC weekly · 2025Review
- Diagnosis of Coxiella burnetii endocarditis by using nanopore targeted sequencing: a case report.BMC infectious diseases · 2025Article
- SFG and TG seropositivity in Humans suspected of TBD in Yucatan, Mexico.Epidemiology and infection · 2025Article
- Case Report: Chronic Q fever mimicking malignancy and tuberculosis in a hemodialysis patient: multidisciplinary diagnosis guided by metagenomic next-generation sequencing.Frontiers in medicine · 2025Article
- Rickettsiosis cases presenting with rash: a case series from an endemic region in Turkey.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Molecular identification of tick-borne Rickettsia, Anaplasma, Ehrlichia, Babesia, and Colpodella in confiscated Malayan pangolins.PLoS neglected tropical diseases · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 5 countries.
Funding
Abstract
Spotted fever group rickettsiae (SFG) are a neglected group of bacteria, belonging to the genus Rickettsia, that represent a large number of new and emerging infectious diseases with a worldwide distribution. The diseases are zoonotic and are transmitted by arthropod vectors, mainly ticks, fleas and mites, to hosts such as wild animals. Domesticated animals and humans are accidental hosts. In Asia, local people in endemic areas as well as travellers to these regions are at high risk of infection. In this review we compare SFG molecular and serological diagnostic methods and discuss their limitations. While there is a large range of molecular diagnostics and serological assays, both approaches have limitations and a positive result is dependent on the timing of sample collection. There is an increasing need for less expensive and easy-to-use diagnostic tests. However, despite many tests being available, their lack of suitability for use in resource-limited regions is of concern, as many require technical expertise, expensive equipment and reagents. In addition, many existing diagnostic tests still require rigorous validation in the regions and populations where these tests may be used, in particular to establish coherent and worthwhile cut-offs. It is likely that the best strategy is to use a real-time quantitative polymerase chain reaction (qPCR) and immunofluorescence assay in tandem. If the specimen is collected early enough in the infection there will be no antibodies but there will be a greater chance of a PCR positive result. Conversely, when there are detectable antibodies it is less likely that there will be a positive PCR result. It is therefore extremely important that a complete medical history is provided especially the number of days of fever prior to sample collection. More effort is required to develop and validate SFG diagnostics and those of other rickettsial infections.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.