ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2019
Cardiomyocyte mechanodynamics under conditions of actin remodelling.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Mechanical Phenotyping of MG63s Following Vibrational Stimulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Microfluidic platforms for monitoring cardiomyocyte electromechanical activity.Microsystems & nanoengineering · 2025Review
- The Role of β-Dystroglycan in Nuclear Dynamics.Cells · 2024Article
- Article
- Visualization of Cell Membrane Tension Regulated by the Microfilaments as a "Shock Absorber" in Micropatterned Cells.Biology · 2023Article
- Impedance spectroscopy of the cell/nanovolcano interface enables optimization for electrophysiology.Microsystems & nanoengineering · 2023Article
- A deformability-based biochip for precise label-free stratification of metastatic subtypes using deep learning.Microsystems & nanoengineering · 2023Article
- Switching in the expression pattern of actin isoforms marks the onset of contractility and distinct mechanodynamic behavior during cardiomyocyte differentiation.Physiological reports · 2022Article
- Passive myocardial mechanical properties: meaning, measurement, models.Biophysical reviews · 2021Review
- Evidence for synergy between sarcomeres and fibroblasts in an in vitro model of myocardial reverse remodeling.Journal of molecular and cellular cardiology · 2021Article
- Fluorescence-based actin turnover dynamics of stem cells as a profiling method for stem cell functional evolution, heterogeneity and phenotypic lineage parsing.Methods (San Diego, Calif.) · 2021Article
- Alterations of housekeeping proteins in human aged and diseased hearts.Pflugers Archiv : European journal of physiology · 2021Article
- Sensing and Responding of Cardiomyocytes to Changes of Tissue Stiffness in the Diseased Heart.Frontiers in cell and developmental biology · 2021Review
- Article
- Single cell ecology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanical performance of cardiomyocytes (CMs) is an important indicator of their maturation state and of primary importance for the development of therapies based on cardiac stem cells. As the mechanical analysis of adherent cells at high-throughput remains challenging, we explore the applicability of real-time deformability cytometry (RT-DC) to probe cardiomyocytes in suspension. RT-DC is a microfluidic technology allowing for real-time mechanical analysis of thousands of cells with a throughput exceeding 1000 cells per second. For CMs derived from human-induced pluripotent stem cells, we determined a Young's modulus of 1.25 ± 0.08 kPa which is in close range to previous reports. Upon challenging the cytoskeleton with cytochalasin D (CytoD) to induce filamentous actin depolymerization, we distinguish three different regimes in cellular elasticity. Transitions are observed below 10 nM and above 10
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