ArticleJournal of neurogastroenterology and motility2019
An Increasing Trend of Eosinophilic Esophagitis in Korea and the Clinical Implication of the Biomarkers to Determine Disease Activity and Treatment Response in Eosinophilic Esophagitis.
Article in Journal of neurogastroenterology and motility, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- Emerging Tissue and Blood Biomarkers for Eosinophilic Esophagitis.Gastroenterology clinics of North America · 2026Review
- Endoscopic Diagnosis of Eosinophilic Esophagitis Using a Multi-Task U-Net: A Pilot Study.Yonsei medical journal · 2026Article
- Eosinophilic Esophagitis: Emerging Insights Into Diagnosis and Management.The Korean journal of helicobacter and upper gastrointestinal research · 2025Review
- Eosinophilic Esophagitis: No Longer a Rarity in Asia-A Growing Concern for Clinicians.The Korean journal of helicobacter and upper gastrointestinal research · 2025Article
- Role of endoscopy in eosinophilic esophagitis.Clinical endoscopy · 2025Review
- Optimal Diagnostic and Treatment Response Threshold of the Eosinophilic Esophagitis Endoscopic Reference Score: A Single-Center Study of 102 Patients With Eosinophilic Esophagitis.Journal of neurogastroenterology and motility · 2024Article
- Eosinophilic esophagitis: absolute eosinophilic count, peak eosinophilic count, and potential biomarkers of eosinophilic degranulation products-an in-depth systematic review.Translational pediatrics · 2024Review
- Eosinophilic gastrointestinal disorders: a narrative review on clinical perspectives and research gaps in the Asian context.Translational gastroenterology and hepatology · 2024Review
- Association betweenThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2023Article
- [Diagnosis and Treatment of Eosinophilic Esophagitis].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Review
- Non-invasive biomarkers of eosinophilic esophagitis.Acta bio-medica : Atenei Parmensis · 2021Review
- 2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2021Review
- Influence of fine particulate matter and its pure particulate fractions on pulmonary immune cells and cytokines in mice.Experimental and therapeutic medicine · 2021Article
- Practice Patterns for Eosinophilic Esophagitis Patients in Busan and Gyeongnam: A Korean Multicenter Database Study.Journal of neurogastroenterology and motility · 2021Article
- Eosinophilic Esophagitis with Angina Pectoris.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2020Article
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
aimsThe epidemiology and pathogenesis of eosinophilic esophagitis (EoE) remain unclear in Asian countries. We investigated clinicopathological characteristics and diagnostic trends of EoE, and evaluated 3 tissue biomarkers for correlation with disease activity and treatment response in Korean patients with EoE.
methodsWe retrospectively reviewed 25 271 esophageal biopsies performed during upper endoscopies between 2006 and 2017. We diagnosed EoE based on ≥ 15 eosinophils/high-power field (HPF) and, symptoms of esophageal dysfunction. We performed immunohistochemical analysis for tryptase, eosinophilic derived neurotoxin (EDN), and eotaxin-3.
resultsWe diagnosed EoE in 72 patients (53 men and 19 women; mean age, 46.2 years) with presenting symptoms of, dysphagia (15.3%), epigastric pain (31.9%), and heartburn (30.6%). The diagnostic rate of EoE considerably increased between 2006 and 2017, from 0.29 diagnoses to 7.99 diagnoses per 1000 esophageal biopsies ( P < 0.001). The mean peak eosinophil count (PEC) was 56.0 (± 77.8)/HPF. Whereas the EDN (rho = 0.667, P < 0.001) and eotaxin-3 levels (rho = 0.465, P < 0.001) correlated with PEC, tryptase and PEC were weakly correlated (rho = 0.291, P = 0.013). EDN (rho = 0.279, P = 0.017), and tryptase (rho = 0.279, P = 0.033) correlated with the inflammatory score of Eosinophilic Esophagitis Endoscopic Reference Score. Immunohistochemical analysis and changes in tryptase, EDN, and eotaxin-3 levels were associated with histologic and endoscopic improvements.
conclusionsEoE incidence considerably increased during the 12-year period, regardless of endoscopic esophageal biopsy rate. Tryptase, EDN, and eotaxin-3 levels in esophageal biopsy specimens could be promising biomarkers for disease activity, symptom, and endoscopic response in Korea.
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