Evidence map›Paper›PMID 31587522›Full record

ArticlePhysiological reports2019

Divergent paths to seizure-like events.

Neela K Codadu, Robert T Graham, Richard J Burman, R Thomas Jackson-Taylor, Joseph V Raimondo, Andrew J Trevelyan, R Ryley Parrish

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Cenobamate reduces epileptiform activity in theFrontiers in neuroscience · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal CortexThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Novel test strategies for in vitro seizure liability assessment.Expert opinion on drug metabolism & toxicology · 2021
    Review
  15. Neuronal Firing and Waveform Alterations through Ictal Recruitment in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  16. Divergent paths to seizure-like events.Physiological reports · 2019
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Neela K CodaduInstitute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.
Robert T GrahamInstitute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.
Richard J BurmanDivision of Cell Biology, Department of Human Biology, Neuroscience Institute and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-3107-7871
R Thomas Jackson-TaylorInstitute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.
Joseph V RaimondoDivision of Cell Biology, Department of Human Biology, Neuroscience Institute and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-8266-3128
Andrew J TrevelyanInstitute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.
R Ryley ParrishInstitute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0001-6798-6140
Newcastle University · GBUniversity of Cape Town · ZA

Funding

Medical Research Council MR/J013250/1Medical Research Council MR/R005427/1
6 · The paper itself

Abstract

Much debate exists about how the brain transitions into an epileptic seizure. One source of confusion is that there are likely to be critical differences between experimental seizure models. To address this, we have compared the evolving activity patterns in two widely used in vitro models of epileptic discharges. Brain slices from young adult mice were prepared in the same way and bathed either in 0 Mg

Indexed as

Disease Models, Animal4-AminopyridineAnimalsBrainEpilepsyFemaleMagnesiumMaleMiceMice, Inbred C57BLOrgan Culture TechniquesSeizures4-AminopyridineMagnesiumEpilepsyictal eventsinterictal eventsinterneurons

Identifiers

PMID31587522
PMCPMC6778598
OpenAlexW2979054536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.