Evidence map›Paper›PMID 31587468›Full record

ArticleDevelopmental neurobiology2020

Expression of a human variant of CHMP2B linked to neurodegeneration in Drosophila external sensory organs leads to cell fate transformations associated with increased Notch activity.

Caroline Wilson, Joshua Kavaler, Syed Tariq Ahmad

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Functional assays inGenome research · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Caroline WilsonDepartment of Biology, Colby College, Waterville, Maine.
Joshua KavalerDepartment of Biology, Colby College, Waterville, Maine.ORCID 0000-0002-4603-5781
Syed Tariq AhmadDepartment of Biology, Colby College, Waterville, Maine.
Colby College · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
NIGMS NIH HHS P20 GM103423
6 · The paper itself

Abstract

Proper function of cell signaling pathways is dependent upon regulated membrane trafficking events that lead to the endocytosis, recycling, and degradation of cell surface receptors. The endosomal complexes required for transport (ESCRT) genes play a critical role in the sorting of ubiquitinated cell surface proteins. CHMP2B

Indexed as

Sense OrgansAnimalsAnimals, Genetically ModifiedCell DifferentiationDisease Models, AnimalDrosophilaDrosophila ProteinsEndosomal Sorting Complexes Required for TransportFrontotemporal DementiaGene Expression Regulation, DevelopmentalHumansNeurodegenerative DiseasesOrganogenesisPupaReceptors, NotchSignal TransductionCHMP2B protein, humanDrosophila ProteinsEndosomal Sorting Complexes Required for TransportN protein, DrosophilaReceptors, NotchbristlesCHMP2BDrosophilaendosomal-lysosomal pathwayfrontotemporal dementiaNotch

Identifiers

PMID31587468
PMCPMC7131872
OpenAlexW2978665336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.