ReviewParasite immunology2020
Immune response to Ichthyophthirius multifiliis and role of IgT.
Review in Parasite immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Vaccination modality and injection site influence the immune response and protection against sea liceBiochemistry and biophysics reports · 2026Article
- Insights into mucosal and systemic immune responses of African catfish, Clarias gariepinus, to chilodonellosis: A natural infection study.Journal of fish biology · 2025Article
- Immunological Responses, Expression of Immune-Related Genes, and Disease Resistance of Rainbow Trout (Animals : an open access journal from MDPI · 2024Article
- Article
- Investigation of Gene Networks in Three Components of Immune System Provides Novel Insights into Immune Response Mechanisms againstAnimals : an open access journal from MDPI · 2023Article
- Responses to pathogen exposure in sentinel juvenile fall-run Chinook salmon in the Sacramento River, CA.Conservation physiology · 2023Article
- The effect of different intensities of the ectoparasitic salmon lice (Lepeophtheirus salmonis) on Atlantic salmon (Salmo salar).Journal of fish diseases · 2022Article
- Functional role of CD40 and CD154 costimulatory signals in IgZ-mediated immunity against bacterial infection.Fish and shellfish immunology reports · 2021Article
- Mucosal immunoglobulins of teleost fish: A decade of advances.Developmental and comparative immunology · 2021Review
- Review
- To React or Not to React: The Dilemma of Fish Immune Systems Facing Myxozoan Infections.Frontiers in immunology · 2021Review
- Quantitative trait loci (QTL) associated with resistance of rainbow trout Oncorhynchus mykiss against the parasitic ciliate Ichthyophthirius multifiliis.Journal of fish diseases · 2020Article
- Immune response to Ichthyophthirius multifiliis and role of IgT.Parasite immunology · 2020Review
- A survey of gyrodactylid parasites on the fins of Homatula variegata in central China.PloS one · 2020Article
- Review on Immersion Vaccines for Fish: An Update 2019.Microorganisms · 2019Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The parasitic ciliate Ichthyophthirius multifiliis causes white spot disease in freshwater fish worldwide. The theront penetrates external surfaces of the naïve fish where it develops into the feeding trophont stage and elicits a protective immune response both at the affected site as well as at the systemic level. The present work compiles data and presents an overall model of the protective reactions induced. A wide spectrum of inflammatory reactions are established upon invasion but the specific protection is provided by adaptive factors. Immunoglobulin IgT is involved in protection of surfaces in several fish species and is thereby one of the first adaptive immune molecules reacting with the penetrating theront. IgT producing lymphocytes occur in epithelia, dispersed or associated with lymphoid cell aggregations (skin epidermis, fins, gills, nostrils and buccal cavities) but they are also present in central immune organs such as the head kidney, spleen and liver. When theronts invade immunized fish skin, they are encountered by host factors which opsonize the parasite and may result in complement activation, phagocytosis or cell-mediated killing. However, antibody (IgT, IgM and IgD) binding to parasite cilia has been suggested to alter parasite behaviour and induce an escape reaction, whereby specific IgT (or other classes of immunoglobulin in fish surfaces) takes a central role in protection against the parasite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.